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Synonyms
ache, acetylcholinesterase, acetylcholine esterase, acetyl cholinesterase, hache, eeache, ache1, huache, tcache, membrane-bound acetylcholinesterase,
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acetylcholine + H2O = choline + acetate
acetylcholine + H2O = choline + acetate
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acetylcholine + H2O = choline + acetate
mechanism
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acetylcholine + H2O = choline + acetate
mechanism
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acetylcholine + H2O = choline + acetate
computer-modelled comparison of ordered uni bi and ki kinetic mechanism. ki model is accurate at equilibrium and when the inhibitor concentration is well below its Kd value
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acetylcholine + H2O = choline + acetate
mathematical modelling of mechanism
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acetylcholine + H2O = choline + acetate
formation of the trigonal bipyramidal transition state
acetylcholine + H2O = choline + acetate
reaction mechanism, structure-function relationship analysis, binding structure and mechanism of substrate and product at both the peripheral and active sites, overview
acetylcholine + H2O = choline + acetate
reaction mechanism, active site structure, the catalytic triad comprises the residues Ser203, His447, Glu334, residues Ser203 and His447 are directly involved in the reaction, serving as nucleophilic attacking group and general acid base catalytic elements, respectively, at the acylation stage of the enzymatic reaction. Modern molecular modeling using tools including molecular docking, molecular dynamics (MD), quantum chemistry and the combined quantum mechanical-molecular mechanical method, overview
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acetylcholine + H2O = choline + acetate
the mechanism for AChE-catalyzed hydrolysis of substrate is formation of the first tetrahedral intermediate via nucleophilic attack of the active site serine
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1,1-dimethyl-4-acetylthiomethylpiperidinium + H2O
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i.e. MATP+, paper spray mass spectrometry is used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces are prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without inhibitor ethyl ((2-[bis(propan-2-yl)amino]ethyl)sulfanyl)(methyl)phosphonate (VX) are mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product is monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay is effective at determining AChE activity and identifying the toxicant, while determination of AChE activity in-solution proceeds at a slower rate. Method evaluation, overview
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1-naphthyl acetate + H2O
1-naphthol + acetate
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a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity
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2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
2,6-dichlorophenolindophenol acetate + H2O
2,6-dichlorophenolindophenol + acetate
2,6-dichlorophenolindophenol acetate computational molecular docking study using the enzyme's crystal structure, PDB ID 4YE7
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2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
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weak substrate
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3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
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weak substrate
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3-(acetamido)-N,N,N-trimethylanilinium + H2O
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slow hydrolysis
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3-(acetamido)-N,N,N-trimethylanilinum + H2O
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ATMA
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3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
6-monoacetylmorphine + H2O
morphine + acetate
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acetyl(beta-methyl)thiocholine iodide + H2O
1-methyl(thio)choline iodide + acetate
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acetyl-(beta-methyl)thiocholine + H2O
(beta-methyl)thiocholine + acetate
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acetyl-(beta-methyl)thiocholine iodide + H2O
acetate + methylthiocholine iodide
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acetyl-beta-methyl-thiocholine + H2O
beta-methyl-thiocholine + acetate
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acetyl-beta-methylcholine + H2O
beta-methylcholine + acetate
acetyl-beta-methylcholine + H2O
methylcholine + acetate
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acetyl-beta-methylthiocholine + H2O
? + acetate
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acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
acetyl-homo-thiocholine + H2O
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acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
acetylcholine + H2O
acetate + choline
acetylcholine + H2O
choline + acetate
acetylcholine chloride + H2O
acetate + choline chloride
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acetylcholine chloride + H2O
choline chloride + acetate
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acetylcholine iodide + H2O
acetate + choline iodide
acetylthiocholine + H2O
acetate + thiocholine
acetylthiocholine + H2O
thiocholine + acetate
acetylthiocholine chloride + H2O
acetate + thiocholine chloride
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acetylthiocholine chloride + H2O
thiocholine chloride + acetate
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acetylthiocholine iodide + H2O
acetate + thiocholine iodide
acetylthiocholine iodide + H2O
thiocholine + acetate
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
alkyl methylphosphonfluoridate + H2O
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oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview
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alpha-naphthyl acetate + H2O
1-naphthol + acetate
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alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
benzoylthiocholine + H2O
thiocholine + benzoate
benzoylthiocholine iodide + H2O
thiocholine iodide + benzoate
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22.2% activity compared to acetylthiocholine
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butylthiocholine + H2O
thiocholine + butanol
butyryl choline + H2O
butyrate + choline
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butyrylthiocholine + H2O
butyrate + thiocholine
butyrylthiocholine + H2O
thiocholine + butanoate
butyrylthiocholine + H2O
thiocholine + butyrate
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
carbachol + H2O
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slow hydrolysis
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cyclopentylcarbonylthiocholine + H2O
thiocholine + cyclopentanecarboxylate
cyclopropylcarbonylthiocholine + H2O
thiocholine + cyclopropanecarboxylate
diisopropyl phosphofluoridate + H2O
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edrophonium chloride + H2O
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heroin + H2O
6-monoacetylmorphine + acetate
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hexanoylthiocholine + H2O
thiocholine + hexanoate
indophenylacetate + H2O
indophenol + acetate
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
3.1.1.7 acetylcholinesterase
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