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Literature summary for 3.1.1.7 extracted from

  • Worek, F.; Herkert, N.M.; Koller, M.; Aurbek, N.; Thiermann, H.
    Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study (2009), Toxicol. Lett., 187, 119-123.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iso-pentylsarin
-
Homo sapiens
additional information pentylsarin derivative inhibitors, structure-activity relationship and inhibition kinetics, overview Homo sapiens
neo-pentylsarin
-
Homo sapiens
n-pentylsarin
-
Homo sapiens
sec-pentylsarin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Homo sapiens acetate + thiocholine
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information rate constants for the inhibition of human erythrocyte AChE by four pentylsarin compounds (ki), for the spontaneous dealkylation (aging, ka) and reactivation (ks) of inhibited AChE as well as for the oximeinduced reactivation of inhibited AChE by obidoxime and HI 6 reflected by the dissociation constant (KD) and the reactivity constant (kr), overview Homo sapiens