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Literature summary for 3.1.1.7 extracted from

  • Silveyra, M.X.; Evin, G.; Montenegro, M.F.; Vidal, C.J.; Martinez, S.; Culvenor, J.G.; Saez-Valero, J.
    Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation (2008), Mol. Cell. Biol., 28, 2908-2919.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
presenilin 1 i.e. PS1, the transmembrane protein plays a critical role in the gamma-secretase processing of the amyloid precursor protein to generate the beta-amyloid peptide, which accumulates in plaques in the pathogenesis of Alzheimer’s disease. The PS1-A246E pathogenic mutation expressed in transgenic mice leads to decreased AChE activity and alteration of AChE glycosylation, accessibility to its peripheral binding site, and the peripheral binding site, which may reflect a shift in protein conformation and disturbed AChE maturation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
semiquantitative PCR expression analysis, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information subcellular co-localization of PS1 and AChE in cultured cells perinuclear rigion and co-expression patterns of PS1 and AChE in brain sections from controls and subjects with sporadic or familial Alzheimer's disease Homo sapiens
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plasma membrane
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Homo sapiens
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perinuclear space perinuclear region of the cytoplasm of cultured cells Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein mutation of presenilin 1 affects the enzyme glycosylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain cerebral, frontal cortex, subcellular co-localization of PS1 and AChE in the perinuclear region of the cytoplasm of cultured cells, and co-expression patterns of PS1 and AChE in brain sections from controls and subjects with sporadic or familial Azlheimer's disease Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine iodide
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Synonyms

Synonyms Comment Organism
AChE
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
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assay at Homo sapiens