Any feedback?
Literature summary for 3.1.1.7 extracted from
- Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission (2009), Phytomedicine, 17, 646-652.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition and blockade of muscarinic receptors by serpentine precursor ajmaline at 0.08 mM, weak by catharanthine at over 0.01 mM, but both compounds inhibit nicotinic receptors in a reversible but non-competitive manner, a more potent nicotinic antagonist is tubocurarine | Rattus norvegicus | |
| physostigmine | - |
Electrophorus electricus |  |
| physostigmine | - |
Rattus norvegicus | |
| serpentine | isolated from aqueous extracts of Catharanthus roseus roots | Electrophorus electricus | |
| serpentine | isolated from aqueous extracts of Catharanthus roseus roots, competitive blockade of muscarinic receptors with high efficiency | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | Rattus norvegicus | - |
acetate + thiocholine | - |
? | |
| acetylthiocholine + H2O | Electrophorus electricus | - |
acetate + thiocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Electrophorus electricus | - |
- |
- |
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Electrophorus electricus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Rattus norvegicus | acetate + thiocholine | - |
? | |
| acetylthiocholine + H2O | - |
Electrophorus electricus | acetate + thiocholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Rattus norvegicus |
| AChE | - |
Electrophorus electricus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Electrophorus electricus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000775 | - |
- |
Electrophorus electricus | serpentine | |
| 0.00645 | - |
- |
Electrophorus electricus | physostigmine | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
