Literature summary for 3.1.1.7 extracted from

Pang, Y.P.; Ekstroem, F.; Polsinelli, G.A.; Gao, Y.; Rana, S.; Hua, D.H.; Andersson, B.; Andersson, P.O.; Peng, L.; Singh, S.K.; Mishra, R.K.; Zhu, K.Y.; Fallon, A.M.; Ragsdale, D.W.; Brimijoin, S.
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases (2009), PLoS ONE, 4, e6851.

Inhibitors

Inhibitors	Comment	Organism
additional information	poor inhibition of 0-2% by N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide, i.e. AMTS17, N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide, i.e. AMTS18, N,N,N-trimethyl-19-(methylsulfonylthio)nonadecan-1-aminium bromide, i.e. AMTS19, and N,N,N-trimethyl-20-(methylsulfonylthio)eicosan-1-aminiumbromide, i.e. i.e. AMTS20	Homo sapiens
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide	i.e. AMTS10, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide	i.e. AMTS10, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide	i.e. AMTS11, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide	i.e. AMTS11, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide	i.e. AMTS12, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide	i.e. AMTS12, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide	i.e. AMTS13, causes a degree of apparently irreversible of the AChE activity in erythrocytes. AMTS13 at 0.006 mM leads to 43% inhibition after 1 h, 70% after 6 h, and 78% after 16 h	Homo sapiens
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide	i.e. AMTS13, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide	i.e. AMTS14, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide	i.e. AMTS14, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide	i.e. AMTS15, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide	i.e. AMTS15, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide	i.e. AMTS16, causes a degree of apparently irreversible of the AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide	i.e. AMTS16, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide	i.e. AMTS17, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity	Schizaphis graminum
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide	i.e. AMTS18, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity	Schizaphis graminum
N,N,N-trimethyl-19-(methylsulfonylthio)nonadecan-1-aminium bromide	i.e. AMTS19, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity	Schizaphis graminum
N,N,N-trimethyl-20-(methylsulfonylthio)eicosan-1-aminiumbromi de	i.e. AMTS20, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity	Schizaphis graminum
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide	i.e. AMTS7, causes weak and purely reversible inhibition of AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide	i.e. AMTS7, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide	i.e. AMTS8, causes weak and purely reversible inhibition of AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide	i.e. AMTS8, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide	i.e. AMTS9, causes weak and purely reversible inhibition of AChE activity in erythrocytes	Homo sapiens
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide	i.e. AMTS9, irreversibly inhibits over 87% of the AChE activity in greenbug extracts	Schizaphis graminum

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Schizaphis graminum	-	greenbug aphid	-

Purification (Commentary)

Purification (Comment)	Organism
native enzyme from greenbug aphids	Homo sapiens
native enzyme from greenbug aphids	Schizaphis graminum

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Homo sapiens
AChE	-	Schizaphis graminum

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens
37	-	assay at	Schizaphis graminum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens
7.4	-	assay at	Schizaphis graminum