Any feedback?
Literature summary for 3.1.1.7 extracted from
- Study of acetylcholinesterase inhibitors using CE with contactless conductivity detection (2009), Electrophoresis, 30, 3442-3448.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| galanthamine | a naturally occurring alkaloid and a drug for the treatment of mild to moderate Alzheimer's disease | Electrophorus electricus |  |
| huperzine A | a reversible AChE inhibitor | Electrophorus electricus | |
| additional information | inhibitor analysis using capillary electrophoresis with contactless conductivity detection, method development, overview | Electrophorus electricus | |
| paraoxon | an organophosphate compound, a quasi-irreversible AChE inhibitor | Electrophorus electricus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Electrophorus electricus | - |
acetate + choline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Electrophorus electricus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Electrophorus electricus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Electrophorus electricus | acetate + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Electrophorus electricus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Electrophorus electricus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Electrophorus electricus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0014 | - |
pH 8.0, 37°C | Electrophorus electricus | huperzine A | |
| 0.0018 | - |
pH 8.0, 37°C | Electrophorus electricus | galanthamine | |
| 0.004 | - |
pH 8.0, 37°C | Electrophorus electricus | paraoxon | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
