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Literature summary for 3.1.1.7 extracted from

  • Mohamed, M.A.; Abdel-Gawad, A.S.; Ghazy, A.E.
    Purification and characterization of an acetylcholinesterase from the infective juveniles of Heterorhabditis bacteriophora (2007), Comp. Biochem. Physiol. C, 146, 314-324.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 isozyme AChE1A, complete competitive inhibition at 0.016 mM Heterorhabditis bacteriophora
eserine isozyme AChE1A, complete competitive inhibition at 0.016 mM Heterorhabditis bacteriophora
additional information no inhibition by iso-OMPA Heterorhabditis bacteriophora

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information MIchaelis-Menten kinetics, activation energy of 9 kcal/mol Heterorhabditis bacteriophora
0.27
-
acetylthiocholine iodide pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora
0.42
-
propionylthiocholine iodide pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora
0.59
-
butyrylthiocholine iodide pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora

Organism

Organism UniProt Comment Textmining
Heterorhabditis bacteriophora
-
eight different Egyptian strains EA2, EB6, EB7, EG7, EG8, EG9, EK1 and EK2, different isozymes, i.e. AChE1A, isozyme pattern
-

Purification (Commentary)

Purification (Comment) Organism
isozyme AChE1A from strain EG9, 17.5fold from infective juveniles, by ammonium sulfate fractionation, gel filtration, and anion exchange chromatography to homogeneity Heterorhabditis bacteriophora

Source Tissue

Source Tissue Comment Organism Textmining
juvenile infective Heterorhabditis bacteriophora
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
34
-
strain EG7 Heterorhabditis bacteriophora
44.2
-
strain EB7 Heterorhabditis bacteriophora
59.1
-
strain EA2 Heterorhabditis bacteriophora
59.9
-
strain EK2 and EK1 Heterorhabditis bacteriophora
60.1
-
strain EG8 Heterorhabditis bacteriophora
71.5
-
strain EB6 Heterorhabditis bacteriophora
82.6
-
strain EG9 Heterorhabditis bacteriophora
1378
-
purified isozyme AChE1A from strain EG9 Heterorhabditis bacteriophora

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine iodide + H2O preferred substrate Heterorhabditis bacteriophora thiocholine iodide + acetate
-
?
benzoylthiocholine iodide + H2O 22.2% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + benzoate
-
?
butyrylthiocholine iodide + H2O 41.7% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + butyrate
-
?
propionylthiocholine iodide + H2O 74.6% activity compared to acetylthiocholine Heterorhabditis bacteriophora thiocholine iodide + propionate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Heterorhabditis bacteriophora
AChE1A
-
Heterorhabditis bacteriophora
ChE1A
-
Heterorhabditis bacteriophora

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Heterorhabditis bacteriophora

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
purified isozyme AChE1A, irreversible inactivation above Heterorhabditis bacteriophora
60
-
30 min, purified isozyme AChE1A, loss of 46% activity Heterorhabditis bacteriophora
70
-
30 min, purified isozyme AChE1A, loss of 63% activity Heterorhabditis bacteriophora
80
-
30 min, purified isozyme AChE1A, loss of 82% activity Heterorhabditis bacteriophora

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Heterorhabditis bacteriophora

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0045
-
BW284c51 pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora
0.005
-
eserine pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora BW284c51
0.0035
-
pH 7.5, 37°C, isozyme AChE1A Heterorhabditis bacteriophora eserine