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Literature summary for 3.1.1.7 extracted from

  • Yang, Z.D.; Duan, D.Z.; Xue, W.W.; Yao, X.J.; Li, S.
    Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships (2012), Life Sci., 90, 929-933.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
conarrhimin strong inhibition, 94% inhibition at 0.1 mg/ml Electrophorus electricus
conessimin strong, reversible and noncompetitive inhibition, 98% inhibition at 0.1 mg/ml Electrophorus electricus
conessine strong inhibition, 95% inhibition at 0.1 mg/ml Electrophorus electricus
conimin strong inhibition, 96% inhibition at 0.1 mg/ml Electrophorus electricus
hookerianamide-F
-
Electrophorus electricus
huperzine A
-
Electrophorus electricus
isoconessimine 55% inhibition at 0.1 mg/ml Electrophorus electricus
additional information total alkaloidal extract from the seeds of Holarrhen antidysenterica strongly inhibit the enzyme with an IC50 value of 0.0061 mg/ml Electrophorus electricus
sarcovagenine-C
-
Electrophorus electricus
sarcovagine-D
-
Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus choline + acetate
-
?
acetylthiocholine + H2O
-
Electrophorus electricus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus huperzine A
0.0015
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus sarcovagenine-C
0.0016
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus hookerianamide-F
0.0022
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus sarcovagine-D
0.004
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus conessimin
0.021
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus conessine
0.023
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus conimin
0.028
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus conarrhimin
0.3
-
IC50 above 0.3 mM, in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C Electrophorus electricus isoconessimine