Inhibitors | Comment | Organism | Structure |
---|---|---|---|
conarrhimin | strong inhibition, 94% inhibition at 0.1 mg/ml | Electrophorus electricus | |
conessimin | strong, reversible and noncompetitive inhibition, 98% inhibition at 0.1 mg/ml | Electrophorus electricus | |
conessine | strong inhibition, 95% inhibition at 0.1 mg/ml | Electrophorus electricus | |
conimin | strong inhibition, 96% inhibition at 0.1 mg/ml | Electrophorus electricus | |
hookerianamide-F | - |
Electrophorus electricus | |
huperzine A | - |
Electrophorus electricus | |
isoconessimine | 55% inhibition at 0.1 mg/ml | Electrophorus electricus | |
additional information | total alkaloidal extract from the seeds of Holarrhen antidysenterica strongly inhibit the enzyme with an IC50 value of 0.0061 mg/ml | Electrophorus electricus | |
sarcovagenine-C | - |
Electrophorus electricus | |
sarcovagine-D | - |
Electrophorus electricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Electrophorus electricus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Electrophorus electricus | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Electrophorus electricus | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | huperzine A | |
0.0015 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | sarcovagenine-C | |
0.0016 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | hookerianamide-F | |
0.0022 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | sarcovagine-D | |
0.004 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | conessimin | |
0.021 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | conessine | |
0.023 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | conimin | |
0.028 | - |
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | conarrhimin | |
0.3 | - |
IC50 above 0.3 mM, in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C | Electrophorus electricus | isoconessimine |