Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Herkert, N.M.; Eckert, S.; Eyer, P.; Bumm, R.; Weber, G.; Thiermann, H.; Worek, F.
    Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors (2008), Toxicology, 246, 188-192.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
paraoxon the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview Homo sapiens
physostigmine 83-85% inhibition at 250 nM of erythrocyte and muscle enzymes, pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE Homo sapiens
pyridostigmine pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE Homo sapiens
soman the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle intercostal muscle Homo sapiens
-
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-acetylthiocholine + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens