Inhibitors | Comment | Organism | Structure |
---|---|---|---|
paraoxon | the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview | Homo sapiens | |
physostigmine | 83-85% inhibition at 250 nM of erythrocyte and muscle enzymes, pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE | Homo sapiens | |
pyridostigmine | pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE | Homo sapiens | |
soman | the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
muscle | intercostal muscle | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-acetylthiocholine + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Homo sapiens | acetate + thiocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |