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Literature summary for 3.1.1.7 extracted from

  • Auletta, J.T.; Johnson, J.L.; Rosenberry, T.L.
    Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase (2010), Chem. Biol. Interact., 187, 135-141.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Drosophila S2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
edrophonium the inhibitor binds specifically to the A-site of the enzyme Homo sapiens
propidium the inhibitor binds specifically to the P-site of the enzyme Homo sapiens
thioflavin T the P-site-specific ligand inhibits the hydrolysis of the rapidly hydrolyzed substrate acetylthiocholine but fails to show any inhibition of the slowly hydrolyzed substrates 3-(acetamido)-N,N,N-trimethylanilinium and carbachol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acetamido)-N,N,N-trimethylanilinium + H2O slow hydrolysis Homo sapiens ?
-
?
acetylcholine + H2O fast hydrolysis Homo sapiens choline + acetate
-
?
acetylthiocholine + H2O fast hydrolysis Homo sapiens thiocholine + acetate
-
?
carbachol + H2O slow hydrolysis Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens