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Literature summary for 3.1.1.7 extracted from

  • Ali, M.Y.; Seong, S.H.; Jung, H.A.; Jannat, S.; Choi, J.S.
    Kinetics and molecular docking of dihydroxanthyletin-type coumarins from Angelica decursiva that inhibit cholinesterase and BACE1 (2018), Arch. Pharm. Res., 41, 753-764 .
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate mixed-type inhibition Electrophorus electricus
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate noncompetitive inhibition Electrophorus electricus
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate mixed-type inhibition Electrophorus electricus
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate mixed-type inhibition Electrophorus electricus
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate mixed-type inhibition Electrophorus electricus
Berberine
-
 Electrophorus electricus
decursidin mixed-type inhibition Electrophorus electricus
additional information evaluation of the potential of six dihydroxanthyletin-type coumarins, isolated from Angelica decursiva, to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE, EC 3.1.1.8), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1, EC 3.4.23.46). AChE protein-ligand docking studies, overview Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus O42275
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Electrophorus electricus choline + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Electrophorus electricus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Electrophorus electricus
0.00332
-
 decursidin pH 8.0, 22°C Electrophorus electricus
0.00472
-
 (6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate pH 8.0, 22°C Electrophorus electricus
0.00489
-
 (6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate pH 8.0, 22°C Electrophorus electricus
0.00544
-
 (6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate pH 8.0, 22°C Electrophorus electricus
0.00744
-
 (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate pH 8.0, 22°C Electrophorus electricus
0.01102
-
 (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate pH 8.0, 22°C Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00109
-
 pH 8.0, 22°C Electrophorus electricus (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
0.00184
-
 pH 8.0, 22°C Electrophorus electricus (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
0.0029
-
 pH 8.0, 22°C Electrophorus electricus (6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
0.00347
-
 pH 8.0, 22°C Electrophorus electricus decursidin
0.00371
-
 pH 8.0, 22°C Electrophorus electricus (6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
0.00401
-
 pH 8.0, 22°C Electrophorus electricus (6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
0.00918
-
 pH 8.0, 22°C Electrophorus electricus Berberine