Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate | mixed-type inhibition | Electrophorus electricus | |
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate | noncompetitive inhibition | Electrophorus electricus | |
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | mixed-type inhibition | Electrophorus electricus | |
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | mixed-type inhibition | Electrophorus electricus | |
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate | mixed-type inhibition | Electrophorus electricus | |
Berberine | - |
Electrophorus electricus | |
decursidin | mixed-type inhibition | Electrophorus electricus | |
additional information | evaluation of the potential of six dihydroxanthyletin-type coumarins, isolated from Angelica decursiva, to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE, EC 3.1.1.8), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1, EC 3.4.23.46). AChE protein-ligand docking studies, overview | Electrophorus electricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Electrophorus electricus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | O42275 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Electrophorus electricus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Electrophorus electricus | choline + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Electrophorus electricus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Electrophorus electricus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Electrophorus electricus | |
0.00332 | - |
decursidin | pH 8.0, 22°C | Electrophorus electricus | |
0.00472 | - |
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | pH 8.0, 22°C | Electrophorus electricus | |
0.00489 | - |
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate | pH 8.0, 22°C | Electrophorus electricus | |
0.00544 | - |
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate | pH 8.0, 22°C | Electrophorus electricus | |
0.00744 | - |
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | pH 8.0, 22°C | Electrophorus electricus | |
0.01102 | - |
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate | pH 8.0, 22°C | Electrophorus electricus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00109 | - |
pH 8.0, 22°C | Electrophorus electricus | (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate | |
0.00184 | - |
pH 8.0, 22°C | Electrophorus electricus | (6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | |
0.0029 | - |
pH 8.0, 22°C | Electrophorus electricus | (6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate | |
0.00347 | - |
pH 8.0, 22°C | Electrophorus electricus | decursidin | |
0.00371 | - |
pH 8.0, 22°C | Electrophorus electricus | (6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate | |
0.00401 | - |
pH 8.0, 22°C | Electrophorus electricus | (6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate | |
0.00918 | - |
pH 8.0, 22°C | Electrophorus electricus | Berberine |