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Literature summary for 3.1.1.7 extracted from

  • Tanoli, N.U.; Tanoli, S.A.K.; Ferreira, A.G.; Mehmood, M.; Gul, S.; Monteiro, J.L.; Vieira, L.C.C.; Venancio, T.; Correa, A.G.; Ul-Haq, Z.
    Characterization of the interactions between coumarin-derivatives and acetylcholinesterase examination by NMR and docking simulations (2018), J. Mol. Model., 24, 207 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxo-N-[2-(piperidin-1-yl)ethyl]-2H-chromene-3-carboxamide
-
Electrophorus electricus
7-hydroxy-3-(piperidin-1-ylcarbonyl)-2H-chromen-2-one
-
Electrophorus electricus
ethyl 2-oxo-7-[2-(piperidin-1-yl)ethoxy]-2H-chromene-3-carboxylate
-
Electrophorus electricus
ethyl 7-hydroxy-8-(3-methoxyphenyl)-2-oxo-2H-chromene-3-carboxylate
-
Electrophorus electricus
additional information designed and molecular recognition studies of coumarin-based inhibitors towards acetylcholinesterase (AChE), molecular docking simulations, dissociation constant and bound conformations of these inhibitors within the inhibitor-AChE complex, overview. The docking simulations mimic NMR results Electrophorus electricus
tacrine
-
Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus O42275
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus choline + acetate
-
?
acetylthiocholine + H2O
-
Electrophorus electricus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

General Information

General Information Comment Organism
physiological function the enzyme acetylcholinesterase (AChE) exists mainly in the synaptic clefts (between nerves and skeletal muscle) and the central nervous system (CNS) of living organisms, and is mostly responsible for proper muscle functioning as well as signal transmissions. AChE hydrolyzes ACh into choline and acetate ion at synapses with a very fast functioning rate, resulting in the loss of stimulatory activity Electrophorus electricus