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Literature summary for 3.1.1.7 extracted from
- Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase (2010), Toxicol. Lett., 195, 142-146.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+)-tabun | - |
Homo sapiens |  |
| (+)-tabun | - |
Sus scrofa | |
| (-)-tabun | - |
Homo sapiens | |
| (-)-tabun | - |
Sus scrofa | |
| additional information | semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview. Aging of tabun-inhibited human AChE, kinetics are similar for the tabun enantiomers, overview | Homo sapiens | |
| additional information | semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | Homo sapiens | - |
acetate + thiocholine | - |
? | |
| acetylthiocholine + H2O | Sus scrofa | - |
acetate + thiocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Homo sapiens | acetate + thiocholine | - |
? | |
| acetylthiocholine + H2O | - |
Sus scrofa | acetate + thiocholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Homo sapiens |
| AChE | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
| additional information | - |
additional information | inhibition kinetics | Sus scrofa |
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