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Literature summary for 3.1.1.7 extracted from

  • Tenberken, O.; Thiermann, H.; Worek, F.; Reiter, G.
    Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase (2010), Toxicol. Lett., 195, 142-146.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview. Aging of tabun-inhibited human AChE, kinetics are similar for the tabun enantiomers, overview Homo sapiens
additional information semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview Sus scrofa
(-)-tabun
-
Homo sapiens
(+)-tabun
-
Homo sapiens
(-)-tabun
-
Sus scrofa
(+)-tabun
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylthiocholine + H2O Homo sapiens
-
acetate + thiocholine
-
?
acetylthiocholine + H2O Sus scrofa
-
acetate + thiocholine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
erythrocyte
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Homo sapiens acetate + thiocholine
-
?
acetylthiocholine + H2O
-
Sus scrofa acetate + thiocholine
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens
AChE
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens
7.4
-
assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Homo sapiens
additional information
-
additional information inhibition kinetics Sus scrofa