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Literature summary for 3.1.1.7 extracted from

  • Gholivand, K.; Abdollahi, M.; Mojahed, F.; Alizadehgan, A.M.; Dehghan, G.
    Acetylcholinesterase/butyrylcholinesterase inhibition activity of some new carbacylamidophosphate derivatives (2009), J. Enzyme Inhib. Med. Chem., 24, 566-576.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(4-bromobenzoyl)phosphoramidic dichloride
-
Homo sapiens
(4-chlorobenzoyl)phosphoramidic dichloride
-
Homo sapiens
(4-methylbenzoyl)phosphoramidic dichloride
-
Homo sapiens
4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
Homo sapiens
4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
Homo sapiens
benzoylphosphoramidic dichloride
-
Homo sapiens
additional information carbacylamidophosphate derivatives, inhibitor synthesis and evaluation in inhibition of acetylcholinesterase and butyrylcholinesterase, EC 3.1.1.8, kinetics and comparisons, overview Homo sapiens
N-[di(morpholin-4-yl)phosphoryl]-4-methylbenzamide
-
Homo sapiens
N-[di(morpholin-4-yl)phosphoryl]benzamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
acetate + choline
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Homo sapiens acetate + choline
-
?
acetylthiocholine + H2O
-
Homo sapiens acetate + thiocholine
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4 7.6 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, overview Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.057
-
pH 7.4, 37°C Homo sapiens 4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
0.087
-
pH 7.4, 37°C Homo sapiens (4-chlorobenzoyl)phosphoramidic dichloride
0.26
-
pH 7.4, 37°C Homo sapiens 4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
0.385
-
pH 7.4, 37°C Homo sapiens (4-bromobenzoyl)phosphoramidic dichloride
0.62
-
pH 7.4, 37°C Homo sapiens N-[di(morpholin-4-yl)phosphoryl]benzamide
0.932
-
pH 7.4, 37°C Homo sapiens benzoylphosphoramidic dichloride
2.89
-
pH 7.4, 37°C Homo sapiens N-[di(morpholin-4-yl)phosphoryl]-4-methylbenzamide
4.15
-
pH 7.4, 37°C Homo sapiens (4-methylbenzoyl)phosphoramidic dichloride