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Literature summary for 3.1.1.7 extracted from

  • Sari, Y.; Aktas, A.; Taslimi, P.; Goek, Y.; Gulcin, I.
    Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes (2018), J. Biochem. Mol. Toxicol., 32, e22009.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3-bis(4-vinylbenzyl)benzylbenzimidazolium
-
Homo sapiens
1,3-bis(N-propylphthalimide)benzylbenzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)-3-(2-methylbenzyl)benzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)-3-(4-methylbenzyl)benzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)-3-benzylbenzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)-3-methylbenzimidazolium
-
Homo sapiens
1-(4-vinylbenzyl)benzimidazole
-
Homo sapiens
1-(N-propylphthalimide)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
-
Homo sapiens
1-(N-propylphthalimide)-3-(3-methylbenzyl)benzimidazolium
-
Homo sapiens
1-(N-propylphthalimide)-3-(4-methylbenzyl)benzimidazolium
-
Homo sapiens
1-(N-propylphthalimide)-3-naphthalenemethylbenzimidazolium
-
Homo sapiens
1-(N-propylphthalimide)benzoimidazole
-
Homo sapiens
additional information development and synthesis of N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts as inhibitors of acetylcholinesterase, structure-activity relationships, overview. Determination of Fe2+ chelating capacities of the compounds Homo sapiens
tacrine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22303
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Homo sapiens choline + acetate
-
?
acetylthiocholine + H2O substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm Homo sapiens thiocholine + acetate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000019
-
1-(N-propylphthalimide)-3-naphthalenemethylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000289
-
1-(N-propylphthalimide)-3-(3-methylbenzyl)benzimidazolium pH 8.0, 37°C Homo sapiens
0.0000325
-
1,3-bis(N-propylphthalimide)benzylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000494
-
1-(N-propylphthalimide)-3-(4-methylbenzyl)benzimidazolium pH 8.0, 37°C Homo sapiens
0.0000508
-
1-(4-vinylbenzyl)-3-(4-methylbenzyl)benzimidazolium pH 8.0, 37°C Homo sapiens
0.0000461
-
1-(4-vinylbenzyl)-3-benzylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000564
-
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000763
-
1-(N-propylphthalimide)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000416
-
1-(N-propylphthalimide)benzoimidazole pH 8.0, 37°C Homo sapiens
0.0001746
-
tacrine pH 8.0, 37°C Homo sapiens
0.0000672
-
1-(4-vinylbenzyl)benzimidazole pH 8.0, 37°C Homo sapiens
0.0000476
-
1-(4-vinylbenzyl)-3-methylbenzimidazolium pH 8.0, 37°C Homo sapiens
0.0000726
-
1-(4-vinylbenzyl)-3-(2-methylbenzyl)benzimidazolium pH 8.0, 37°C Homo sapiens
0.0000335
-
1,3-bis(4-vinylbenzyl)benzylbenzimidazolium pH 8.0, 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000318
-
pH 8.0, 37°C Homo sapiens 1-(N-propylphthalimide)-3-(3-methylbenzyl)benzimidazolium
0.0000348
-
pH 8.0, 37°C Homo sapiens 1,3-bis(N-propylphthalimide)benzylbenzimidazolium
0.0000621
-
pH 8.0, 37°C Homo sapiens 1-(N-propylphthalimide)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
0.0000454
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)-3-methylbenzimidazolium
0.0002044
-
pH 8.0, 37°C Homo sapiens tacrine
0.0000883
-
pH 8.0, 37°C Homo sapiens 1-(N-propylphthalimide)benzoimidazole
0.0000688
-
pH 8.0, 37°C Homo sapiens 1-(N-propylphthalimide)-3-(4-methylbenzyl)benzimidazolium
0.0000561
-
pH 8.0, 37°C Homo sapiens 1-(N-propylphthalimide)-3-naphthalenemethylbenzimidazolium
0.0001178
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)benzimidazole
0.0000739
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)-3-(4-methylbenzyl)benzimidazolium
0.0000739
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)-3-benzylbenzimidazolium
0.0000832
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)-3-(2-methylbenzyl)benzimidazolium
0.0000755
-
pH 8.0, 37°C Homo sapiens 1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
0.0000604
-
pH 8.0, 37°C Homo sapiens 1,3-bis(4-vinylbenzyl)benzylbenzimidazolium