Application | Comment | Organism |
---|---|---|
diagnostics | the enzyme has potential as biomarker of pesticides and metal ions | Hoplosternum littorale |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aldicarb | - |
Hoplosternum littorale | |
As3+ | - |
Hoplosternum littorale | |
BW284c51 | - |
Hoplosternum littorale | |
Carbaryl | - |
Hoplosternum littorale | |
carbofuran | - |
Hoplosternum littorale | |
Cd2+ | - |
Hoplosternum littorale | |
chlorpyrifos | - |
Hoplosternum littorale | |
Cu2+ | - |
Hoplosternum littorale | |
diazinon | - |
Hoplosternum littorale | |
dichlorvos | - |
Hoplosternum littorale | |
Diflubenzuron | - |
Hoplosternum littorale | |
eserine | - |
Hoplosternum littorale | |
Hg2+ | - |
Hoplosternum littorale | |
iso-ompa | - |
Hoplosternum littorale | |
neostigmine | - |
Hoplosternum littorale | |
novaluron | - |
Hoplosternum littorale | |
parathion-methyl | - |
Hoplosternum littorale | |
Pb2+ | - |
Hoplosternum littorale | |
pyriproxyfen | - |
Hoplosternum littorale | |
temephos | - |
Hoplosternum littorale | |
Zn2+ | - |
Hoplosternum littorale |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Hoplosternum littorale | |
1.47 | - |
acetylthiocholine | pH 8.0, 30°C | Hoplosternum littorale |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no or poor effects by 1 mM of Fe2+, Mn2+, Mg2+, and K+ | Hoplosternum littorale |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Hoplosternum littorale | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hoplosternum littorale | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Hoplosternum littorale | - |
central nervous system | - |
Hoplosternum littorale | - |
neuron | - |
Hoplosternum littorale | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Hoplosternum littorale | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Hoplosternum littorale | thiocholine + acetate | - |
? | |
additional information | activity detection with chromogenic reagent 5,5'-dithiobis-(2-nitrobenzoic) acid (DTNB) | Hoplosternum littorale | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Hoplosternum littorale |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Hoplosternum littorale |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | 45 | over 70% of maximal activity within this range | Hoplosternum littorale |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
100% activity remaining | Hoplosternum littorale |
40 | - |
80% activity remaining | Hoplosternum littorale |
50 | - |
no activity remaining | Hoplosternum littorale |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8100 | - |
acetylthiocholine | pH 8.0, 30°C | Hoplosternum littorale |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Hoplosternum littorale |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000145 | - |
neostigmine | pH 8.0, 30°C | Hoplosternum littorale | |
0.0000184 | - |
BW284c51 | pH 8.0, 30°C | Hoplosternum littorale | |
0.0000247 | - |
eserine | pH 8.0, 30°C | Hoplosternum littorale | |
0.000035 | - |
iso-ompa | pH 8.0, 30°C | Hoplosternum littorale |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 8.0, 30°C | Hoplosternum littorale | eserine | |
0.00034 | - |
pH 8.0, 30°C | Hoplosternum littorale | neostigmine | |
0.00196 | - |
pH 8.0, 30°C | Hoplosternum littorale | BW284c51 | |
0.00483 | - |
pH 8.0, 30°C | Hoplosternum littorale | iso-ompa |
General Information | Comment | Organism |
---|---|---|
physiological function | acetylcholinesterase (AChE) is a serine hydrolase, whose main function is to modulate neurotransmission at cholinergic synapses. It is, therefore, the primary target of some pesticides and heavy metals. Its inhibition in aquatic organisms has been used as an indicator of the presence of these pollutants in water bodies. Acetylcholinesterase is a key enzyme in the regulation of synaptic transmission. AChE promotes the hydrolysis of the neurotransmitter, acetylcholine, to ensure intermittent nerve impulses (which characterize neuronal communication) while preventing acute cholinergic syndrome that can result if this neurotransmitter accumulates in the nerve endings of the central and peripheral nervous system | Hoplosternum littorale |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5510 | - |
acetylthiocholine | pH 8.0, 30°C | Hoplosternum littorale |