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Literature summary for 3.1.1.7 extracted from

  • Bartling, A.; Worek, F.; Szinicz, L.; Thiermann, H.
    Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase (2007), Toxicology, 233, 166-172.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cyclosarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
ethylsarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
iso-butylsarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
methylsarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
n-butylsarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
n-propylsarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
organophosphorus compounds determination of reactivation efficiency with oxims, e.g. obixime, 2-PAM, HI 6, HLö 7, and MMB-4, reactivation kinetics, overview, structure-activity relationship for inhibition and spontaneous reactivation, overview Homo sapiens
sarin a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens
soman a methylfluorophosphonate, enzyme reactivation by oximes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylthiocholine + H2O Homo sapiens
-
thiocholine + acetate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Homo sapiens thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Homo sapiens