Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione | - |
Homo sapiens | |
2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione | - |
Homo sapiens | |
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate | - |
Homo sapiens | |
dimethyl [(10R)-10-(4-methoxyphenyl)-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]propanedioate | - |
Homo sapiens | |
dimethyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]propanedioate | - |
Homo sapiens | |
dimethyl [(4R)-4,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate | - |
Homo sapiens | |
dimethyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate | - |
Homo sapiens | |
dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate | - |
Homo sapiens | |
dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate | - |
Homo sapiens | |
methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate | - |
Homo sapiens | |
methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate | - |
Homo sapiens | |
methyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]acetate | - |
Homo sapiens | |
neostigmine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Homo sapiens | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | neostigmine | |
0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione | |
0.0063 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate | |
0.012 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate | |
0.01435 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate | |
0.03512 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate | |
0.04676 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate | |
0.06532 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione | |
0.07535 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate |