Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Maia, A.; Schmitz-Afonso, I.; Martin, M.T.; Awang, K.; Laprevote, O.; Gueritte, F.; Litaudon, M.
    Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors (2008), Planta Med., 74, 1457-1462.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
giganteone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
maingayone B isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
maingayone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
malabaricone A isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
malabaricone B isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
malabaricone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
promalabaricone B
-
Electrophorus electricus
promalabaricone C
-
Electrophorus electricus
tacrine
-
Electrophorus electricus

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Electrophorus electricus acetate + thiocholine iodide
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0094
-
-
Electrophorus electricus malabaricone B
0.011
-
-
Electrophorus electricus malabaricone A
0.0117
-
-
Electrophorus electricus malabaricone C
0.07
-
above Electrophorus electricus giganteone C
0.07
-
above Electrophorus electricus maingayone B
0.07
-
above Electrophorus electricus maingayone C
0.07
-
above Electrophorus electricus giganteone A
0.115
-
-
Electrophorus electricus tacrine
0.14
-
above Electrophorus electricus promalabaricone B
0.14
-
above Electrophorus electricus promalabaricone C