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Results 1 - 10 of 445 > >>
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.71,1-dimethyl-4-acetylthiomethylpiperidinium + H2O i.e. MATP+, paper spray mass spectrometry is used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces are prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without inhibitor ethyl ((2-[bis(propan-2-yl)amino]ethyl)sulfanyl)(methyl)phosphonate (VX) are mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product is monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay is effective at determining AChE activity and identifying the toxicant, while determination of AChE activity in-solution proceeds at a slower rate. Method evaluation, overview Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.71-naphthyl acetate + H2O a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity Homo sapiens 1-naphthol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72,6-dichloro-3'-methylindophenylacetate + H2O - Neptunea eulimata 2,6-dichloro-3'-methylindophenol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72,6-dichloro-3'-methylindophenylacetate + H2O weak substrate Homo sapiens 2,6-dichloro-3'-methylindophenol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72,6-dichlorophenolindophenol acetate + H2O 2,6-dichlorophenolindophenol acetate computational molecular docking study using the enzyme's crystal structure, PDB ID 4YE7 Homo sapiens 2,6-dichlorophenolindophenol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72,6-dichlorophenolindophenylacetate + H2O - Homo sapiens 2,6-dichlorophenolindophenol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72,6-dichlorophenolindophenylacetate + H2O - Neptunea eulimata 2,6-dichlorophenolindophenol + acetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72-methoxyacetylthiocholine + H2O recombinant enzyme shows about 12% activity compared to acetylthiocholine Homo sapiens thiocholine + 2-methoxyacetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.72-methoxyacetylthiocholine + H2O recombinant enzyme shows about 65% activity compared to acetylthiocholine Lucilia cuprina thiocholine + 2-methoxyacetate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.73',5'-dichloro-2'-methylindophenylacetate + H2O weak substrate Homo sapiens 3',5'-dichloro-2'-methylindophenol + acetate - ?
Results 1 - 10 of 445 > >>