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Literature summary for 3.1.1.7 extracted from

  • Jazi, R.; Lalonde, R.; Qian, S.; Strazielle, C.
    Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice (2009), Neurosci. Res., 63, 106-114.
    View publication on PubMed
Search for more literature for 3.1.1.7

Activating Compound

Activating Compound Comment Organism Structure
presenilin 1 PS1, required for enzyme activity in the brain, overview. PS1-deficient mice show upregulation of AChE activity in major cholinergic cell nuclei and in cortical and thalamic regions responsible for selective attention and visuomotor coordination, as well as limbic structures with related regions involved in cognition, arousal, emotion, and plasticit, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
amygdala
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 Mus musculus
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brain medial septum, vertical diagonal band,substantia inominata, eye field, posterior parietal and visual cortices, posterior thalamic and lateral geniculate nuclei, hippocampal formation and amygdala, midline, periventricular, reticular thalamic nuclei, and lateral prefrontal, agranular insular cortices Mus musculus
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cerebral cortex
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 Mus musculus
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corpus striatum
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 Mus musculus
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forebrain
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 Mus musculus
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hippocampus
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 Mus musculus
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additional information brain tissue localization of AChE, overview Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 enzyme activity in wild-type and PS1/A246E transgenic mice, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
AChE
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 Mus musculus