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Literature summary for 3.1.1.7 extracted from
- Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: Is there a structure-activity relationship? (2010), Chem. Biol. Interact., 187, 215-219.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ethyl N,N-di-isopropylphosphorofluoridate | - |
Homo sapiens |  |
| ethyl N,N-di-n-propylphosphoamidocyanidate | - |
Homo sapiens | |
| ethyl N,N-diethylphosphorofluoridate | - |
Homo sapiens | |
| ethyl N-ethylphosphorofluoridate | - |
Homo sapiens | |
| ethyl N-methylphosphorofluoridate | - |
Homo sapiens | |
| ethyl N-n-propylphosphorofluoridate | - |
Homo sapiens | |
| ethylsarin | - |
Homo sapiens | |
| iso-pentylsarin | - |
Homo sapiens | |
| methylsarin | - |
Homo sapiens | |
| additional information | inhibitory potencies of sarin and tabun derivatives, overview | Homo sapiens | |
| n-butylsarin | - |
Homo sapiens | |
| n-pentylsarin | - |
Homo sapiens | |
| n-propylsarin | - |
Homo sapiens | |
| neo-pentylsarin | - |
Homo sapiens | |
| sarin | - |
Homo sapiens | |
| sec-pentylsarin | - |
Homo sapiens | |
| Tabun | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Homo sapiens | - |
acetate + choline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Homo sapiens | acetate + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Homo sapiens |
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Release 2023.1 (January 2023)
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