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Literature summary for 3.1.1.7 extracted from

  • Aurbek, N.; Herkert, N.M.; Koller, M.; Thiermann, H.; Worek, F.
    Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: Is there a structure-activity relationship? (2010), Chem. Biol. Interact., 187, 215-219.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ethyl N-ethylphosphorofluoridate
-
Homo sapiens
ethyl N-methylphosphorofluoridate
-
Homo sapiens
ethyl N,N-diethylphosphorofluoridate
-
Homo sapiens
ethyl N,N-di-isopropylphosphorofluoridate
-
Homo sapiens
ethyl N,N-di-n-propylphosphoamidocyanidate
-
Homo sapiens
ethyl N-n-propylphosphorofluoridate
-
Homo sapiens
ethylsarin
-
Homo sapiens
iso-pentylsarin
-
Homo sapiens
methylsarin
-
Homo sapiens
additional information inhibitory potencies of sarin and tabun derivatives, overview Homo sapiens
n-butylsarin
-
Homo sapiens
neo-pentylsarin
-
Homo sapiens
n-pentylsarin
-
Homo sapiens
n-propylsarin
-
Homo sapiens
sarin
-
Homo sapiens
sec-pentylsarin
-
Homo sapiens
Tabun
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
acetate + choline
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Homo sapiens acetate + choline
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Homo sapiens