Literature summary for 3.1.1.7 extracted from

Paz, A.; Xie, Q.; Greenblatt, H.M.; Fu, W.; Tang, Y.; Silman, I.; Qiu, Z.; Sussman, J.L.
The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad (2009), J. Med. Chem., 52, 2543-2549.

Crystallization (Commentary)

Crystallization (Comment)	Organism
purified enzyme with bound bis-(-)-nor-meptazinol derivative 3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol, trigonal crystals of the enzyme are soaked for 20 h at 4°C in 0.002 ml of 1 mM 5h dissolved in the crystallization solution containing 40% PEG 200 v/v, 150 mM MES, pH 7.4, by hanging drop procedure, X-ray diffraction structure determination and analysis at 2.7 A resolution	Tetronarce californica

Crystallization (Comment)

Organism

purified enzyme with bound bis-(-)-nor-meptazinol derivative 3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol, trigonal crystals of the enzyme are soaked for 20 h at 4°C in 0.002 ml of 1 mM 5h dissolved in the crystallization solution containing 40% PEG 200 v/v, 150 mM MES, pH 7.4, by hanging drop procedure, X-ray diffraction structure determination and analysis at 2.7 A resolution

Tetronarce californica

Inhibitors

Inhibitors	Comment	Organism	Structure
3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol	binding by a bis-(-)-nor-meptazinol derivative disrupts the catalytic triad, structure analysis and molecular docking, overview	Tetronarce californica

Organism

Organism	UniProt	Comment	Textmining
Tetronarce californica	P04058	-	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Tetronarce californica

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Release 2023.1 (January 2023)