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Literature summary for 3.1.1.7 extracted from

  • Rozengart, E.; Yagodina, O.; Basova, N.; Saakov, V.
    Substrate-inhibitor specificity of cholinesterase and monoamine oxydase from optic ganglia of the pacific squid Todarodes pacificus and commander squid Berryteuthis magister (2017), J. Evol. Biochem. Physiol., 53, 111-122 .
No PubMed abstract available
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
 Berryteuthis magister
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
 Todarodes pacificus
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
 Berryteuthis magister
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
 Todarodes pacificus
2-acetamido-N,N,N-trimethylethen-1-aminium reversible inhibitor Berryteuthis magister
2-acetamido-N,N,N-trimethylethen-1-aminium reversible inhibitor Todarodes pacificus
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium reversible inhibitor Berryteuthis magister
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium reversible inhibitor Todarodes pacificus
4-acetyl-1,1-dimethylpiperazin-1-ium reversible inhibitor Berryteuthis magister
4-acetyl-1,1-dimethylpiperazin-1-ium reversible inhibitor Todarodes pacificus
dipropan-2-yl phosphorofluoridate
-
 Berryteuthis magister
dipropan-2-yl phosphorofluoridate
-
 Todarodes pacificus
additional information organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship Berryteuthis magister
additional information organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship Todarodes pacificus
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Berryteuthis magister
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Todarodes pacificus
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Berryteuthis magister
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Todarodes pacificus
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Berryteuthis magister
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Todarodes pacificus
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Berryteuthis magister
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) reversible inhibitor Todarodes pacificus
N,N,N-triethylethanaminium reversible inhibitor Berryteuthis magister
N,N,N-triethylethanaminium reversible inhibitor Todarodes pacificus
N,N,N-trimethylmethanaminium reversible inhibitor Berryteuthis magister
N,N,N-trimethylmethanaminium reversible inhibitor Todarodes pacificus
O,O-diethyl S-hexyl phosphorothioate
-
 Berryteuthis magister
O,O-diethyl S-hexyl phosphorothioate
-
 Todarodes pacificus
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
 Berryteuthis magister
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
 Todarodes pacificus
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
 Berryteuthis magister
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
 Todarodes pacificus
O-ethyl S-heptyl methylphosphonothioate
-
 Berryteuthis magister
O-ethyl S-heptyl methylphosphonothioate
-
 Todarodes pacificus
O-ethyl S-hexyl methylphosphonothioate
-
 Berryteuthis magister
O-ethyl S-hexyl methylphosphonothioate
-
 Todarodes pacificus
O-ethyl S-neopentyl methylphosphonothioate
-
 Berryteuthis magister
O-ethyl S-neopentyl methylphosphonothioate
-
 Todarodes pacificus
O-ethyl S-pentyl methylphosphonothioate
-
 Berryteuthis magister
O-ethyl S-pentyl methylphosphonothioate
-
 Todarodes pacificus
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
 Berryteuthis magister
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
 Todarodes pacificus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Todarodes pacificus
-
 choline + acetate
-
 ?
acetylcholine + H2O Berryteuthis magister
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Berryteuthis magister
-
 different populations from the Central Kuril Islands region, the Olyutor-Navarin region (Bering Sea), and the Prybylovo-Alaska region (Bering Sea)
-
Todarodes pacificus
-
 different populations from autumn and winter
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series Todarodes pacificus
-
additional information ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series Berryteuthis magister
-
optic ganglion
-
 Todarodes pacificus
-
optic ganglion
-
 Berryteuthis magister
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-beta-methylcholine + H2O
-
 Todarodes pacificus beta-methylcholine + acetate
-
 ?
acetyl-beta-methylcholine + H2O
-
 Berryteuthis magister beta-methylcholine + acetate
-
 ?
acetylcholine + H2O
-
 Todarodes pacificus choline + acetate
-
 ?
acetylcholine + H2O
-
 Berryteuthis magister choline + acetate
-
 ?
acetylthiocholine + H2O
-
 Todarodes pacificus thiocholine + acetate
-
 ?
acetylthiocholine + H2O
-
 Berryteuthis magister thiocholine + acetate
-
 ?
additional information acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 Todarodes pacificus ?
-
 ?
additional information acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 Berryteuthis magister ?
-
 ?
N-2-acetoxyethyl-N-methylpiperidinium + H2O
-
 Todarodes pacificus ?
-
 ?
N-2-acetoxyethyl-N-methylpiperidinium + H2O
-
 Berryteuthis magister ?
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Todarodes pacificus
AChE
-
 Berryteuthis magister
Acylcholine acylhydrolase
-
 Todarodes pacificus
Acylcholine acylhydrolase
-
 Berryteuthis magister
ChE
-
 Todarodes pacificus
ChE
-
 Berryteuthis magister
More cf. EC 3.1.1.8 Todarodes pacificus
More cf. EC 3.1.1.8 Berryteuthis magister

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Todarodes pacificus
25
-
 assay at Berryteuthis magister

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Todarodes pacificus
7.5
-
 assay at Berryteuthis magister

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics of enzymes from different populations, inhibition type, overview Todarodes pacificus
additional information
-
 additional information inhibition kinetics of enzymes from different populations, inhibition type, overview Berryteuthis magister

General Information

General Information Comment Organism
physiological function a key enzyme of the cholinergic nervous system Todarodes pacificus
physiological function a key enzyme of the cholinergic nervous system Berryteuthis magister