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Literature summary for 3.1.1.7 extracted from
- In vitro characterization of cholinesterases in the earthworm Eisenia andrei (2006), Comp. Biochem. Physiol. C, 143C, 416-421.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BW284c51 | specific inhibition of acetylthiocholinesterase activity | Eisenia andrei |  |
| Carbaryl | - |
Eisenia andrei | |
| eserine | - |
Eisenia andrei | |
| additional information | no inhibition by iso-OMPA | Eisenia andrei |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.142 | - |
acetylthiocholine iodide | pH 7.4, 25°C | Eisenia andrei | |
| 0.183 | - |
propionylthiocholine iodide | pH 7.4, 25°C | Eisenia andrei | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Eisenia andrei | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.004 | - |
substrate butyrylthiocholine iodide | Eisenia andrei |
| 0.0425 | - |
substrate acetylthiocholine iodide | Eisenia andrei |
| 0.0498 | - |
substrate propionylthiocholine iodide | Eisenia andrei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine iodide + H2O | - |
Eisenia andrei | thiocholine iodide + acetate | - |
? | |
| butyrylthiocholine iodide + H2O | - |
Eisenia andrei | thiocholine iodide + butyrate | - |
? | |
| propionylthiocholine iodide + H2O | preferred substrate | Eisenia andrei | thiocholine iodide + propionate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ChE | - |
Eisenia andrei |
| cholinesterase | - |
Eisenia andrei |
| More | cf. EC 3.1.1.8 | Eisenia andrei |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Eisenia andrei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Eisenia andrei |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000479 | - |
pH 7.4, 25°C, versus propionylthiocholine | Eisenia andrei | Carbaryl | |
| 0.00000575 | - |
pH 7.4, 25°C, versus acetylthiocholine | Eisenia andrei | Carbaryl | |
| 0.000012 | - |
pH 7.4, 25°C, versus propionylthiocholine | Eisenia andrei | eserine | |
| 0.0000144 | - |
pH 7.4, 25°C, versus acetylthiocholine | Eisenia andrei | eserine | |
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