Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BW284c51 | reversible inhibitor | Dugesia japonica | |
Carbaryl | low inhibition, irreversible inhibitor | Dugesia japonica | |
chlorpyrifos oxon | irreversible inhibitor | Dugesia japonica | |
diazinon oxon | high inhibition, irreversible inhibitor | Dugesia japonica | |
dichlorvos | irreversible inhibitor | Dugesia japonica | |
donepezil | reversible inhibitor | Dugesia japonica | |
edrophonium | reversible inhibitor | Dugesia japonica | |
ethopropazine | reversible inhibitor | Dugesia japonica | |
malaoxon | low inhibition, irreversible inhibitor | Dugesia japonica | |
additional information | the quaternary pyridinium aldoximes, pralidoxime (2-PAM) and a lead zwitterionic oxime (RS194B), are both able to reactivate DjChE ATCh hydrolyzing activity at concentrations of 4 mM. Also NaF can reactivate DjChE activity, and the rate of reactivation shows a linear dependence on fluoride concentration. Reactivation of DjChE is significantly more rapid with 10 mM NaF than with 4 mM 2-PAM | Dugesia japonica | |
neostigmine | high inhibition, irreversible inhibitor | Dugesia japonica | |
paraoxon | irreversible inhibitor | Dugesia japonica | |
physostigmine | irreversible inhibitor | Dugesia japonica | |
propidium | reversible inhibitor | Dugesia japonica | |
pyridostigmine | irreversible inhibitor | Dugesia japonica | |
tacrine | reversible inhibitor | Dugesia japonica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Dugesia japonica | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dugesia japonica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Dugesia japonica | choline + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATCh | - |
Dugesia japonica |
cholinesterase | - |
Dugesia japonica |
DjChE | - |
Dugesia japonica |
More | cf. EC 3.1.1.8 | Dugesia japonica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Dugesia japonica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Dugesia japonica |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Dugesia japonica |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | BW284c51 | |
0.03 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | propidium | |
0.031 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | edrophonium | |
0.032 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | BW284c51 | |
0.062 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | tacrine | |
0.069 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | donepezil | |
0.089 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | donepezil | |
0.093 | - |
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine | Dugesia japonica | ethopropazine | |
0.13 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | ethopropazine | |
0.14 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | tacrine | |
0.16 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | edrophonium | |
0.3 | - |
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine | Dugesia japonica | propidium |
General Information | Comment | Organism |
---|---|---|
evolution | as one of the most ancient true cholinesterases, DjChE provides insight into the evolution of a hybrid enzyme before the separation into distinct AChE and BChE enzymes found in higher vertebrates | Dugesia japonica |
physiological function | the majority of Dugesia japonica cholinesterase (DjChE) activity departs from conventional AChE and BChE classifications | Dugesia japonica |