Cloned (Comment) | Organism |
---|---|
recombinant expression of HuAChE in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-huperzine A | - |
Homo sapiens | |
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide | i.e. BW284c51 | Homo sapiens | |
acetylthiocholine | - |
Homo sapiens | |
butyrylthiocholine | - |
Homo sapiens | |
decamethonium | - |
Homo sapiens | |
diisopropyl fluorophosphate | inhibition, aging, and reactivation kinetics | Homo sapiens | |
edrophonium | - |
Homo sapiens | |
ethopropazine | - |
Homo sapiens | |
additional information | recombinant HuAChE shows substrate inhibition | Homo sapiens | |
phenothiazine | - |
Homo sapiens | |
propidium | - |
Homo sapiens | |
propionylthiocholine | - |
Homo sapiens | |
tacrine | - |
Homo sapiens | |
tetra(monoisopropyl)diphosphortetramide | irreversible | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
acetylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens | |
0.15 | - |
propionylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Homo sapiens | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22303 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme HuAChE from CHO cells by procainamide affinity chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
additional information | no activity with butyrylcholine | Homo sapiens | ? | - |
? | |
propionylthiocholine + H2O | - |
Homo sapiens | thiocholine + propionate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
HuAChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.72 | - |
propionylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens | |
7.18 | - |
acetylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000032 | - |
(-)-huperzine A | pH 8.0, 22°C | Homo sapiens | |
0.000003 | - |
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide | pH 8.0, 22°C | Homo sapiens | |
0.000037 | - |
tacrine | pH 8.0, 22°C | Homo sapiens | |
0.00036 | - |
edrophonium | pH 8.0, 22°C | Homo sapiens | |
0.00049 | - |
propidium | pH 8.0, 22°C | Homo sapiens | |
0.0022 | - |
decamethonium | pH 8.0, 22°C | Homo sapiens | |
0.0046 | - |
tetra(monoisopropyl)diphosphortetramide | pH 8.0, 22°C | Homo sapiens | |
0.0653 | - |
ethopropazine | pH 8.0, 22°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the concentration of active sites in rHuAChE is determined by titration with 7-(O,O-diethyl-phosphinyloxy)-1-methylquinolinium methylsulfate (DEPQ) | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
24.8 | - |
propionylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens | |
65.3 | - |
acetylthiocholine | recombinant enzyme, pH 8.0, 22°C | Homo sapiens |