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Literature summary for 3.1.1.7 extracted from

  • Fujiwara, M.; Yagi, N.; Miyazawa, M.
    Acetylcholinesterase inhibitory activity of volatile oil from Peltophorum dasyrachis Kurz ex Bakar (yellow batai) and Bisabolane-type sesquiterpenoids (2010), J. Agric. Food Chem., 58, 2824-2829.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(7S,9R)-ar-turmerol a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
(7S,9R)-dihydro-arturmerol a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
(7S,9S)-arturmerol a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
(7S,9S)-dihydro-ar-turmerol a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
additional information chemical compositions and acetylcholinesterase inhibitory activitiy of the volatile oil from the bark of Peltophorum dasyrachis, yellow batai, IC50 value is 0.083 mg/ml, overview. The order of AChE inhibitory potency by bisabolane-type sesquiterpenoids is: ketones > alcohols > hydrocarbons, Structure-activity relationships of inhibitors, overview Homo sapiens
(S)-ar-curcumene a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
(S)-ar-turmerone sesquiterpenoid, a competitive inhibitor Homo sapiens
(S)-dihydro-ar-curcumene a synthetic bisabolane-type sesquiterpenoid derivative Homo sapiens
(S)-dihydro-ar-turmerone a sesquiterpenoid, a noncompetitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
acetate + choline
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Homo sapiens acetate + choline
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, overview Homo sapiens
0.882
-
(S)-ar-turmerone
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1911
-
-
Homo sapiens (S)-ar-turmerone
0.0815
-
-
Homo sapiens (S)-dihydro-ar-turmerone