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Literature summary for extracted from

  • Young, S.; Fabio, K.; Guillon, C.; Mohanta, P.; Halton, T.A.; Heck, D.E.; Flowers, R.A.; Laskin, J.D.; Heindel, N.D.
    Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction (2010), Bioorg. Med. Chem. Lett., 20, 2987-2990.
    View publication on PubMedView publication on EuropePMC


Application Comment Organism
drug development development of inhibitors with therapeutic potential to dually target inflammation by releasing an non-steroidal anti-inflammatory drug, e.g. ibuprofen, naproxen, indomethacin, or diclofenac, in vivo and activating the cholinergic anti-inflammatory pathway via cholinergic up-regulation, overview Homo sapiens


Inhibitors Comment Organism Structure
additional information design and study of two classes of noncompetitive acetylcholinesterase inhibitors, which also function as non-steroidal anti-inflammatory drug prodrugs. The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an non-steroidal anti-inflammatory drug and a lipophilic choline mimic, and they inhibit AChE in the submicromolar range, overview Homo sapiens


Organism UniProt Comment Textmining
Homo sapiens


Synonyms Comment Organism
Homo sapiens