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Literature summary for 3.1.1.7 extracted from

  • Young, S.; Fabio, K.; Guillon, C.; Mohanta, P.; Halton, T.A.; Heck, D.E.; Flowers, R.A.; Laskin, J.D.; Heindel, N.D.
    Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction (2010), Bioorg. Med. Chem. Lett., 20, 2987-2990.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.7

Application

Application Comment Organism
drug development development of inhibitors with therapeutic potential to dually target inflammation by releasing an non-steroidal anti-inflammatory drug, e.g. ibuprofen, naproxen, indomethacin, or diclofenac, in vivo and activating the cholinergic anti-inflammatory pathway via cholinergic up-regulation, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information design and study of two classes of noncompetitive acetylcholinesterase inhibitors, which also function as non-steroidal anti-inflammatory drug prodrugs. The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an non-steroidal anti-inflammatory drug and a lipophilic choline mimic, and they inhibit AChE in the submicromolar range, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
AChE
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 Homo sapiens