Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one | i.e. BZYX, an indanone derivative, and a dual-binding-site AChE inhibitor. BZYX also shows high neuroprotection from H2O2-induced apoptosis in PC12 cells and prevents loss of membrane potential, determination with fluorescent 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazol-carbocyanine iodide, i.e. JC-1, overview | Rattus norvegicus | |
donepezil | - |
Rattus norvegicus | |
galanthamine | - |
Rattus norvegicus | |
huperzine A | - |
Rattus norvegicus | |
rivastigmine | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Rattus norvegicus | acetate + thiocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000019 | - |
pH 7.4, 37°C | Rattus norvegicus | donepezil | |
0.000053 | - |
pH 7.4, 37°C | Rattus norvegicus | huperzine A | |
0.000058 | - |
pH 7.4, 37°C | Rattus norvegicus | (E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one | |
0.00301 | - |
pH 7.4, 37°C | Rattus norvegicus | galanthamine | |
0.00381 | - |
pH 7.4, 37°C | Rattus norvegicus | rivastigmine |