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Literature summary for 3.1.1.7 extracted from

  • Gabrovska, K.; Marinov, I.; Godjevargova, T.; Portaccio, M.; Lepore, M.; Grano, V.; Diano, N.; Mita, D.G.
    The influence of the support nature on the kinetics parameters, inhibition constants and reactivation of immobilized acetylcholinesterase (2008), Int. J. Biol. Macromol., 43, 339-345.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information AChE immobilization on two different composite membranes constituted by a chemically modified poly-acrylonitrile membrane plus a layer of tethered chitosan of different molecular weight, 10 kDa or 400 kDa, or directly on a chemically modified poly-acrylonitrile membrane with NaOH and ethylenediamine without chitosan, method development and enzyme activities, the best performance is obtained by the modified poly-acrylonitrile membrane having the chitosan with the lower molecular weight, overview Electrophorus electricus

Inhibitors

Inhibitors Comment Organism Structure
paraoxon-methyl inhibition mechanism and reactivation of paraoxon-methyl-inhibited AChE by pyridine-2-aldoxime methochloride, overview Electrophorus electricus
pyridine-2-aldoxime methochloride inhibition mechanism Electrophorus electricus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics of soluble and immobilized enzymes, overview Electrophorus electricus
0.9
-
acetylthiocholine iodide pH 7.4, 30°C, soluble free enzyme Electrophorus electricus
2.48 9.55 acetylthiocholine iodide pH 7.4, 35°C, poly-acrylonitrile-membrane immobilized enzymes Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline acetate + choline
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Electrophorus electricus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
AChE activity of the soluble enzyme form and in the insoluble enzyme form with all the three types of modified poly-acrylonitrile membranes, overview Electrophorus electricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus acetate + choline
-
?
acetylcholine + H2O acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline Electrophorus electricus acetate + choline
-
?
acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Electrophorus electricus acetate + thiocholine iodide
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
free enzyme, assay at Electrophorus electricus
35
-
immobilized enzyme, assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Electrophorus electricus