1.14.14.86: ent-kaurene monooxygenase
This is an abbreviated version!
For detailed information about ent-kaurene monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.86
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1.14.14.86
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gibberellin
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ent-kaurenoic
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fujikuroi
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ent-copalyl
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rebaudiana
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paclobutrazol
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3-oxidase
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steviol
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ga20ox
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uniconazole
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biotechnology
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copalyl
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stevioside
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8'-hydroxylase
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molecular biology
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synthesis
- 1.14.14.86
- gibberellin
-
ent-kaurenoic
- fujikuroi
-
ent-copalyl
- rebaudiana
- paclobutrazol
-
3-oxidase
- steviol
- ga20ox
- uniconazole
- biotechnology
-
copalyl
- stevioside
-
8'-hydroxylase
- molecular biology
- synthesis
Reaction
Synonyms
AtKO, CYP701, CYP701A, CYP701A26, CYP701A3, CYP701A50, CYP701A51, CYP701A6, CYP701B1, EC 1.14.13.78, EKO, ent-kaurene oxidase, ent-kaurene oxidase 2, ent-kaurene oxidase-like protein, kaurene oxidase, KO, KO1, KO2, KOS1, KOS2, KOS3, KOS4, More, MtKO, OsKO, OsKO2, P450-4, PsKO1, SmKO, TwKO
ECTree
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Reference on EC 1.14.14.86 - ent-kaurene monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sherwin, P.F.; Coates, R.M.
Stereospecificity of the oxidation of ent-kauren-19-ol to ent-kaurenal by a microsomal enzyme preparation from Marah macrocarpus
J. Chem. Soc.
1982
1013-1014
1982
Marah macrocarpa
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Ashman, P.J.; Mackenzie, A.; Bramley, P.M.
Characterization of ent-kaurene oxidase activity from Gibberella fujikuroi
Biochim. Biophys. Acta
1036
151-157
1990
Cucurbita maxima, Fusarium fujikuroi, Fusarium fujikuroi SG78, Malus sp.
Archer, C.; Ashman, P.J.; Hedden, P.; Bowyer, J.R.; Bramley, P.M.
Purification of ent-kaurene oxidase from Gibberella fujikuroi and Cucurbita maxima
Biochem. Soc. Trans.
20
218S
1992
Cucurbita maxima, Fusarium fujikuroi
Helliwell, C.A.; Poole, A.; Peacock, W.J.; Dennis, E.S.
Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis
Plant Physiol.
119
507-510
1999
Arabidopsis thaliana
Helliwell, C.A.; Sullivan, J.A.; Mould, R.M.; Gray, J.C.; Peacock, W.J.; Dennis, E.S.
A plastid envelope location of Arabidopsis ent-kaurene oxidase links the plastid and endoplasmic reticulum steps of the gibberellin biosynthesis pathway
Plant J.
28
201-208
2001
Arabidopsis thaliana (Q93ZB2), Arabidopsis thaliana
Tudzynski, B.; Hedden, P.; Carrera, E.; Gaskin, P.
The P450-4 gene of Gibberella fujikuroi encodes ent-kaurene oxidase in the gibberellin biosynthesis pathway
Appl. Environ. Microbiol.
67
3514-3522
2001
Fusarium fujikuroi, Fusarium fujikuroi (O94142)
Swain, S.M.; Singh, D.P.; Helliwell, C.A.; Poole, A.T.
Plants with increased expression of ent-kaurene oxidase are resistant to chemical inhibitors of this gibberellin biosynthesis enzyme
Plant Cell Physiol.
46
284-291
2005
Arabidopsis thaliana
Davidson, S.E.; Smith, J.J.; Helliwell, C.A.; Poole, A.T.; Reid, J.B.
The pea gene LH encodes ent-kaurene oxidase
Plant Physiol.
134
1123-1134
2004
Pisum sativum (Q6XAF4), Pisum sativum
Sakamoto, T.; Miura, K.; Itoh, H.; Tatsumi, T.; Ueguchi-Tanaka, M.; Ishiyama, K.; Kobayashi, M.; Agrawal, G.K.; Takeda, S.; Abe, K.; Miyao, A.; Hirochika, H.; Kitano, H.; Ashikari, M.; Matsuoka, M.
An overview of gibberellin metabolism enzyme genes and their related mutants in rice
Plant Physiol.
134
1642-1653
2004
Oryza sativa
Malonek, S.; Rojas, M.C.; Hedden, P.; Gaskin, P.; Hopkins, P.; Tudzynski, B.
Functional characterization of two cytochrome P450 monooxygenase genes, P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D)
Appl. Environ. Microbiol.
71
1462-1472
2005
Fusarium proliferatum (Q701P2), Fusarium proliferatum
Humphrey, T.V.; Richman, A.S.; Menassa, R.; Brandle, J.E.
Spatial organisation of four enzymes from Stevia rebaudiana that are involved in steviol glycoside synthesis
Plant Mol. Biol.
61
47-62
2006
Stevia rebaudiana
Zhu, S.; Gao, F.; Cao, X.; Chen, M.; Ye, G.; Wei, C.; Li, Y.
The rice dwarf virus P2 protein interacts with ent-kaurene oxidases in vivo, leading to reduced biosynthesis of gibberellins and rice dwarf symptoms
Plant Physiol.
139
1935-1945
2005
Oryza sativa Japonica Group (Q68YV7), Oryza sativa Japonica Group (Q68YV9), Oryza sativa Japonica Group (Q6GZ42), Oryza sativa (Q68YV8)
Sawada, Y.; Katsumata, T.; Kitamura, J.; Kawaide, H.; Nakajima, M.; Asami, T.; Nakaminami, K.; Kurahashi, T.; Mitsuhashi, W.; Inoue, Y.; Toyomasu, T.
Germination of photoblastic lettuce seeds is regulated via the control of endogenous physiologically active gibberellin content, rather than of gibberellin responsiveness
J. Exp. Bot.
59
3383-3393
2008
Lactuca sativa (B5MEX5), Lactuca sativa (B5MEX6)
Ko, K.W.; Lin, F.; Katsumata, T.; Sugai, Y.; Miyazaki, S.; Kawaide, H.; Okada, K.; Nojiri, H.; Yamane, H.
Functional identification of a rice ent-kaurene oxidase, OsKO2, using the Pichia pastoris expression system
Biosci. Biotechnol. Biochem.
72
3285-3288
2008
Oryza sativa
Morrone, D.; Chen, X.; Coates, R.M.; Peters, R.J.
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis
Biochem. J.
431
337-344
2010
Arabidopsis thaliana (Q93ZB2), Arabidopsis thaliana, Arabidopsis thaliana Columbia (Q93ZB2)
Okazaki, M.; Nimitkeatkai, H.; Muramatsu, T.; Aoyama, H.; Ueno, K.; Mizutani, M.; Hirai, N.; Kondo, S.; Ohnishi, T.; Todoroki, Y.
Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8-hydroxylase CYP707A
Bioorg. Med. Chem.
19
406-413
2011
Oryza sativa, Oryza sativa Nipponbare
Lei, L.; Fan, Z.; Tang, L.; Chen, F.
Molecular cloning and identification of tissue-specific expression of ent-kaurene oxidase gene in Momordica charantia
Afr. J. Biotechnol.
10
15724-15730
2011
Momordica charantia (D5LXQ4)
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Miyazaki, S.; Katsumata, T.; Natsume, M.; Kawaide, H.
The CYP701B1 of Physcomitrella patens is an ent-kaurene oxidase that resists inhibition by uniconazole-P
FEBS Lett.
585
1879-1883
2011
Physcomitrium patens (F2ZAE0), Physcomitrium patens
Hamberger, B.; Ohnishi, T.; Hamberger, B.; Seguin, A.; Bohlmann, J.
Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects
Plant Physiol.
157
1677-1695
2011
Picea sitchensis
Wang, Q.; Hillwig, M.L.; Wu, Y.; Peters, R.J.
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism
Plant Physiol.
158
1418-1425
2012
Oryza sativa
Villa-Ruano, N.; Lozoya-Gloria, E.; Betancourt-Jimenez, M.; Herlt, T.; Pacheco-Hernandez, Y.; Castro-Juarez, C.
Functional characterization of ent-kaurene oxidase, MtKO, from Montanoa tomentosa (zoapatle)
Arch. Biol. Sci.
67
193-199
2015
Montanoa tomentosa
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Todoroki, Y.; Naiki, K.; Muramatsu, T.; Ohnishi, T.; Ueno, K.; Mizutani, M.; Hirai, N.
A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6
Bioorg. Med. Chem. Lett.
22
3240-3243
2012
Oryza sativa Japonica Group (Q5Z5R4)
Mao, H.; Shen, Q.; Wang, Q.
CYP701A26 is characterized as an ent-kaurene oxidase with putative involvement in maize gibberellin biosynthesis
Biotechnol. Lett.
39
1709-1716
2017
Zea mays
Su, P.; Guan, H.; Zhang, Y.; Wang, X.; Gao, L.; Zhao, Y.; Hu, T.; Zhou, J.; Ma, B.; Tu, L.; Tong, Y.; Huang, L.; Gao, W.
Probing the single key amino acid responsible for the novel catalytic function of ent-kaurene oxidase supported by NADPH-cytochrome P450 reductases in Tripterygium wilfordii
Front. Plant Sci.
8
1756
2017
Tripterygium wilfordii
Noguchi, C.; Miyazaki, S.; Kawaide, H.; Gotoh, O.; Yoshida, Y.; Aoyama, Y.
Characterization of moss ent-kaurene oxidase (CYP701B1) using a highly purified preparation
J. Biochem.
163
69-76
2018
Physcomitrium patens, Physcomitrium patens (F2ZAE0)
Yamamura, Y.; Taguchi, Y.; Ichitani, K.; Umebara, I.; Ohshita, A.; Kurosaki, F.; Lee, J.B.
Characterization of ent-kaurene synthase and kaurene oxidase involved in gibberellin biosynthesis from Scoparia dulcis
J. Nat. Med.
72
456-463
2018
Scoparia dulcis (A0A0N7H9X2), Scoparia dulcis (A0A0N9YKX0), Scoparia dulcis
Itoh, H.; Tatsumi, T.; Sakamoto, T.; Otomo, K.; Toyomasu, T.; Kitano, H.; Ashikari, M.; Ichihara, S.; Matsuoka, M.
A rice semi-dwarf gene, Tan-Ginbozu (D35), encodes the gibberellin biosynthesis enzyme, ent-kaurene oxidase
Plant Mol. Biol.
54
533-547
2004
Oryza sativa Japonica Group (Q5Z5R4)
Mafu, S.; Jia, M.; Zi, J.; Morrone, D.; Wu, Y.; Xu, M.; Hillwig, M.L.; Peters, R.J.
Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis
Proc. Natl. Acad. Sci. USA
113
2526-2531
2016
Oryza sativa Japonica Group (Q5Z5R4), Arabidopsis thaliana (Q93ZB2)
Su, P.; Tong, Y.; Cheng, Q.; Hu, Y.; Zhang, M.; Yang, J.; Teng, Z.; Gao, W.; Huang, L.
Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway
Sci. Rep.
6
23057
2016
Salvia miltiorrhiza (A0A0G2RKY1), Salvia miltiorrhiza
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