1.14.14.86: ent-kaurene monooxygenase
This is an abbreviated version!
For detailed information about ent-kaurene monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.86
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1.14.14.86
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gibberellin
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ent-kaurenoic
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fujikuroi
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ent-copalyl
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rebaudiana
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paclobutrazol
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3-oxidase
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steviol
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ga20ox
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uniconazole
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biotechnology
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copalyl
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stevioside
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8'-hydroxylase
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molecular biology
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synthesis
- 1.14.14.86
- gibberellin
-
ent-kaurenoic
- fujikuroi
-
ent-copalyl
- rebaudiana
- paclobutrazol
-
3-oxidase
- steviol
- ga20ox
- uniconazole
- biotechnology
-
copalyl
- stevioside
-
8'-hydroxylase
- molecular biology
- synthesis
Reaction
Synonyms
AtKO, CYP701, CYP701A, CYP701A26, CYP701A3, CYP701A50, CYP701A51, CYP701A6, CYP701B1, EC 1.14.13.78, EKO, ent-kaurene oxidase, ent-kaurene oxidase 2, ent-kaurene oxidase-like protein, kaurene oxidase, KO, KO1, KO2, KOS1, KOS2, KOS3, KOS4, More, MtKO, OsKO, OsKO2, P450-4, PsKO1, SmKO, TwKO
ECTree
1.14.14.86 ent-kaurene monooxygenaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.14.14.86 - ent-kaurene monooxygenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(-)-kaurene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
(-)-kaurenoic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
16alpha-hydroxy-ent-kaurane + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-ent-kauranoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
ent-kaur-16-ene + 3 NADPH + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
ent-kaur-16-ene-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
involved in gibberilin biosynthesis pathway
-
?
ent-kaur-16-ene-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oic acid + [oxidized NADPH-hemoprotein reductase] + H2O
ent-kaur-16-ene-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
ent-kaurene + [reduced NADPH-hemoprotein reductase] + O2
(-)-kaurenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
(-)-kaurene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
(-)-kaurenoic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Q68YV8
the enzyme plays a key role in the biosynthesis of plant growth hormones gibberellins
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-
?
(-)-kaurene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
(-)-kaurenoic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Q68YV7, Q68YV9, Q6GZ42
the enzyme plays a key role in the biosynthesis of plant growth hormones gibberellins
-
-
?
(-)-kaurene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
(-)-kaurenoic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
last step in gibberellic acid biosynthesis, before the branch point for steviol production, pathway overview
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-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
three step oxidation process via ent-kaurenol and ent-kaurenal, in co-operation with membrane-associated cytochrome P450 monooxygenase
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-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-en-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
-
?
ent-kaur-16-ene + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
ent-kaur-16-en-19-oate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
overall reaction
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
part of gibberelin biosynthetic pathway, decreased KO levels increase the sensitivity to KO inhibitors
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
involved in gibberilin biosynthesis pathway
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaur-16-ene + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-ene-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-ene-19-al + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-oic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaur-16-ene-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
-
?
ent-kaur-16-ene-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
involved in gibberilin biosynthesis pathway
-
?
ent-kaur-16-ene-19-ol + [reduced NADPH-hemoprotein reductase] + O2
ent-kaur-16-en-19-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
-
?
ent-kaurene + [reduced NADPH-hemoprotein reductase] + O2
(-)-kaurenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ent-kaurene + [reduced NADPH-hemoprotein reductase] + O2
(-)-kaurenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
ent-kaurene + [reduced NADPH-hemoprotein reductase] + O2
(-)-kaurenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
additional information
?
-
the enzyme catalyzes three hydroxylation reactions, which further requires dehydration at some stage, overview
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-
?
additional information
?
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-
the enzyme catalyzes three hydroxylation reactions, which further requires dehydration at some stage, overview
-
-
?
additional information
?
-
the enzyme catalyzes three hydroxylation reactions, which further requires dehydration at some stage, overview
-
-
?
additional information
?
-
the enzyme is involved in the biosynthetic pathway and metabolism of gibberellins. Gibberellin mediates the control of seed germination by phytochrome mainly via the control of the endogenous content of bioactive gibberellic acid, rather than the control of gibberellic acid responsiveness, gibberellin metabolism and signalling in lettuce seed, overview
-
-
?
additional information
?
-
the enzyme is involved in the biosynthetic pathway and metabolism of gibberellins. Gibberellin mediates the control of seed germination by phytochrome mainly via the control of the endogenous content of bioactive gibberellic acid, rather than the control of gibberellic acid responsiveness, gibberellin metabolism and signalling in lettuce seed, overview
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-
?
additional information
?
-
Q68YV8
the rice dwarf virus P2 protein interacts with ent-kaurene oxidase isozymes in vivo, leading to reduced enzyme expression and biosynthesis of gibberellins and rice dwarf symptoms, mechanism, overview
-
-
?
additional information
?
-
-
CYP701A catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid, a biosynthetic precursor of the plant hormone gibberellin
-
-
?
additional information
?
-
Q68YV7
the rice dwarf virus P2 protein interacts with ent-kaurene oxidase isozymes in vivo, leading to reduced enzyme expression and biosynthesis of gibberellins and rice dwarf symptoms, mechanism, overview
-
-
?
additional information
?
-
Q68YV9
the rice dwarf virus P2 protein interacts with ent-kaurene oxidase isozymes in vivo, leading to reduced enzyme expression and biosynthesis of gibberellins and rice dwarf symptoms, mechanism, overview
-
-
?
additional information
?
-
Q6GZ42
the rice dwarf virus P2 protein interacts with ent-kaurene oxidase isozymes in vivo, leading to reduced enzyme expression and biosynthesis of gibberellins and rice dwarf symptoms, mechanism, overview
-
-
?
additional information
?
-
-
CYP701A catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid, a biosynthetic precursor of the plant hormone gibberellin
-
-
?
additional information
?
-
-
the enzyme is involved in sweet steviol glycoside synthesis, the diterpene steviol which is produced from a branch of the gibberellic acid biosynthetic pathway, spatial organization, overview
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-
?
additional information
?
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-
the enzyme catalyzes the three-step oxidation of the C4alpha methyl of the tetracyclic diterpene intermediate ent-kaurene to form ent-kaurenoic acid. It can also convert 16alpha-hydroxy-ent-kaurane to 16alpha-hydroxy-ent-kaurenoic acid
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?
