1.14.14.86: ent-kaurene monooxygenase
This is an abbreviated version!
For detailed information about ent-kaurene monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.86
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1.14.14.86
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gibberellin
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ent-kaurenoic
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fujikuroi
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ent-copalyl
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rebaudiana
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paclobutrazol
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3-oxidase
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steviol
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ga20ox
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uniconazole
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biotechnology
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copalyl
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stevioside
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8'-hydroxylase
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molecular biology
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synthesis
- 1.14.14.86
- gibberellin
-
ent-kaurenoic
- fujikuroi
-
ent-copalyl
- rebaudiana
- paclobutrazol
-
3-oxidase
- steviol
- ga20ox
- uniconazole
- biotechnology
-
copalyl
- stevioside
-
8'-hydroxylase
- molecular biology
- synthesis
Reaction
Synonyms
AtKO, CYP701, CYP701A, CYP701A26, CYP701A3, CYP701A50, CYP701A51, CYP701A6, CYP701B1, EC 1.14.13.78, EKO, ent-kaurene oxidase, ent-kaurene oxidase 2, ent-kaurene oxidase-like protein, kaurene oxidase, KO, KO1, KO2, KOS1, KOS2, KOS3, KOS4, More, MtKO, OsKO, OsKO2, P450-4, PsKO1, SmKO, TwKO
ECTree
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Inhibitors
Inhibitors on EC 1.14.14.86 - ent-kaurene monooxygenase
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(1E)-1-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol
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(1E,3S)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol
i.e. uniconazole
(5E)-6-tert-butyl-5-[(4-chlorophenyl)methylidene]-5,6-dihydro-8H-[1,2,4]triazolo[5,1-c][1,4]oxazine
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(5E)-6-tert-butyl-5-[(4-nitrophenyl)methylidene]-5,6-dihydro-8H-[1,2,4]triazolo[5,1-c][1,4]oxazine
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(E)-2-(2-((1-(4-(3-hydroxy-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)ethyl 4-methylbenzenesulfonate
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i.e. abscinazole-E1, orUT1-E2Ts, or Abz-E1, a specific potent inhibitor of ABA 8'-hydroxylase, EC 1.14.13.93, but a weak inhibitor of CYP701A, both in vitro and in vivo
methyl (2E)-3-[1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazol-5-yl]prop-2-enoate
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uniconazole
selective binding of CYP701B1 with uniconazole, is directly bound to the heme iron with its azole nitrogen
additional information
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among the azoles known as CYP51 inhibitors, ketoconazole, an antifungal medicine, is one of the most potent CYP51 inhibitor and forms a one-to-one complex with CYP51 as with uniconazole and CYP701B1. But ketoconazole does not bind and inhibit the purified ent-kaurene oxidase, CYP701B1; not inhibitory: ketoconazole
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additional information
among the azoles known as CYP51 inhibitors, ketoconazole, an antifungal medicine, is one of the most potent CYP51 inhibitor and forms a one-to-one complex with CYP51 as with uniconazole and CYP701B1. But ketoconazole does not bind and inhibit the purified ent-kaurene oxidase, CYP701B1; not inhibitory: ketoconazole
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