1.14.14.86: ent-kaurene monooxygenase
This is an abbreviated version!
For detailed information about ent-kaurene monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.86
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1.14.14.86
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gibberellin
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ent-kaurenoic
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fujikuroi
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ent-copalyl
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rebaudiana
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paclobutrazol
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3-oxidase
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steviol
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ga20ox
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uniconazole
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biotechnology
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copalyl
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stevioside
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8'-hydroxylase
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molecular biology
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synthesis
- 1.14.14.86
- gibberellin
-
ent-kaurenoic
- fujikuroi
-
ent-copalyl
- rebaudiana
- paclobutrazol
-
3-oxidase
- steviol
- ga20ox
- uniconazole
- biotechnology
-
copalyl
- stevioside
-
8'-hydroxylase
- molecular biology
- synthesis
Reaction
Synonyms
AtKO, CYP701, CYP701A, CYP701A26, CYP701A3, CYP701A50, CYP701A51, CYP701A6, CYP701B1, EC 1.14.13.78, EKO, ent-kaurene oxidase, ent-kaurene oxidase 2, ent-kaurene oxidase-like protein, kaurene oxidase, KO, KO1, KO2, KOS1, KOS2, KOS3, KOS4, More, MtKO, OsKO, OsKO2, P450-4, PsKO1, SmKO, TwKO
ECTree
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General Information
General Information on EC 1.14.14.86 - ent-kaurene monooxygenase
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metabolism
physiological function
additional information
metabolism
kaurene oxidase is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4alpha methyl of the ent-kaurene olefin intermediate into the carboxylic acid moiety of ent-kauren-19-oic acid
metabolism
oxidation of ent-kaurene to ent-kaurenoic acid is a common process in gibberellin biosynthesis by vascular plants and production of gibberellin-like compounds by nonvascular plants
metabolism
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oxidation of ent-kaurene to ent-kaurenoic acid is involved in gibberellin biosynthesis
metabolism
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the enzyme catalyzes the three-step oxidation of the C4alpha methyl of the tetracyclic diterpene intermediate ent-kaurene to form ent-kaurenoic acid as an early step in gibberellin (GA) biosynthesis, gibberellin phytohormone biosynthesis, pathway overview
metabolism
the enzyme is involved in the in the gibberellin biosynthetic pathway, it catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid
metabolism
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kaurene oxidase is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4alpha methyl of the ent-kaurene olefin intermediate into the carboxylic acid moiety of ent-kauren-19-oic acid
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kaurene oxidase is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4alpha methyl of the ent-kaurene olefin intermediate into the carboxylic acid moiety of ent-kauren-19-oic acid
physiological function
in the gibberellin biosynthetic pathway. CPSent catalyzes the cyclization of geranylgeranyl diphosphate to ent-copalyl diphosphate, which is converted to ent-kaurene by kaurene synthase. Then, kaurene oxidase catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid
physiological function
natural mutant d35Tan-Ginbozu mutant plants reached 6070% of the height of wild-type throughout the vegetative development. All internodes of d35Tan-Ginbozu are shortened in comparison to the wild-type, mutation induces stunted culms by gibberellic acid deficiency
physiological function
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the enzyme catalyzes the three-step oxidation of the C4alpha methyl of the tetracyclic diterpene intermediate ent-kaurene to form ent-kaurenoic acid as an early step in gibberellin (GA) biosynthesis. It can also convert 16alpha-hydroxy-ent-kaurane to 16alpha-hydroxy-ent-kaurenoic acid, indicating an important function of 16alpha-hydroxy-ent-kaurane in the anti-HIV principle tripterifordin biosynthetic pathway in planta
physiological function
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the enzyme is involved in gibberellin biosynthesis and catalyzes carboxylation on C19 of ent-kaurene to generate ent-kaurenoic acid in plastids. The tetracyclic diterpenoid plant hormones, gibberellins, play important roles during the entire life cycle of higher plants including cell elongation, flowering and fruit set, seed germination, and many other developmental processes
physiological function
the multiply reactive cytochrome P450, ent-kaurene oxidase (KO), is involved in production of the diterpenoid plant hormone gibberellin
physiological function
the multiply reactive cytochrome P450, ent-kaurene oxidase (KO), is involved in production of the diterpenoid plant hormone gibberellin
physiological function
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kaurene oxidase is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4alpha methyl of the ent-kaurene olefin intermediate into the carboxylic acid moiety of ent-kauren-19-oic acid
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a modular metabolic engineering system is used in a combinatorial biosynthetic approach to detect substrates of ent-kaurene oxidase, overview
additional information
a modular metabolic engineering system is used in a combinatorial biosynthetic approach to detect substrates of ent-kaurene oxidase, overview
additional information
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enzyme structur homology modeling and molecular docking, using the crystal structure of cytochrome P450 monooxygenase CYP170A1 from Streptomyces coelicolor, PDB ID 3DBG, as template. Key residue Leu387 contributes to the formation of 16alpha-hydroxy-ent-kaurenoic acid, most likely by forming hydrogen bonds with the hydroxyl group of 16alpha-hydroxy-ent-kaurane, multifunctional nature of kaurene oxidase catalysis, overview