1.5.3.24: sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)
This is an abbreviated version!
For detailed information about sarcosine oxidase (5,10-methylenetetrahydrofolate-forming), go to the full flat file.
Reaction
Synonyms
heterotetrameric sarcosine oxidase, HSO, sarcosine oxidase, sarcosine oxidase P, sarcosine: oxygen oxidoreductase (demethylating), sarcosine:oxygen oxidoreductase (demethylating), TSOX
ECTree
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Systematic Name
Systematic Name on EC 1.5.3.24 - sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)
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sarcosine, 5,6,7,8-tetrahydrofolate:O2 oxidoreductase (demethylating, 5,10-methylenetetrahydrofolate-forming)
The enzyme, found in some bacterial species, is composed of four different subunits and two active sites connected by a large "reaction chamber". An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde. The enzyme contains three cofactors: noncovalently bound FAD and NAD+, and FMN that is covalently bound to a histidine residue. In the absence of folate the enzyme catalyses the reaction of EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming).