EC Number   |
General Information |
Reference |
|---|
   2.3.2.34 | malfunction |
enzyme depletion results in decreased DNA-dependent protein kinase catalytic subunit neddylation |
756386 |
| 2.3.2.34 | malfunction |
knocking down Ube2m leads to decreased Nedd8-ylation of endogenous cullins 1-4, and a marginal increase in Nedd8-modified cullin 5 By contrast, knocking down Ube2f virtually eliminates the presence of Nedd8-ylated cullin 5, and has no effect on the levels of Nedd8-modified cullins 1-4 |
757647 |
| 2.3.2.34 | metabolism |
the enzyme incorporates with E3 neddylation ligase to induce cullin-RING ligase-5 neddylation, leading to activation of cullin-RING ligase-5 E3 to promote NOXA polyubiquitylation via K11 linkage for proteasomal degradation |
755751 |
| 2.3.2.34 | metabolism |
the N-terminal extension of Ubc12 is a selective peptide motif that optimally recruits NEDD8 E1 for the NEDD8 transfer cascade and plays an important role in mitogenesis |
757786 |
| 2.3.2.34 | metabolism |
UBC12 pairs with RBX1/ROC1 to regulate the neddylation of cullin 1, 2, 3, 4a, 4b and 7, while UBE2F pairs with RBX2/ROC2 to regulate the neddylation of cullin 5 |
756564 |
| 2.3.2.34 | physiological function |
UBE2M is a dual E2 for targeted ubiquitylation and degradation of UBE2F, acting as a neddylation E2 to activate cullin 3-Keap1 E3 under physiological condition, but as an ubiquitylation E2 for Parkin-DJ-1 E3 under stressed conditions. UBE2M-induced UBE2F degradation leads to CRL5 inactivation and subsequent NOXA accumulation to suppress the growth of lung cancer cells |
757651 |
