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Literature summary for 2.3.2.34 extracted from

  • Guo, Z.; Wang, S.; Xie, Y.; Han, Y.; Hu, S.; Guan, H.; Xie, D.; Bai, C.; Liu, X.; Gu, Y.; Zhou, P.K.; Ma, T.
    HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response (2020), Cell Death Dis., 11, 400 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.34

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine Homo sapiens
-
 [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme participates in neddylation of DNA-dependent protein kinase catalytic subunit Homo sapiens ?
-
-
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
neddylation E2-conjugating enzyme
-
 Homo sapiens
UBE2M
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme depletion results in decreased DNA-dependent protein kinase catalytic subunit neddylation Homo sapiens