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Literature summary for 2.3.2.34 extracted from

  • Huang, D.T.; Ayrault, O.; Hunt, H.W.; Taherbhoy, A.M.; Duda, D.M.; Scott, D.C.; Borg, L.A.; Neale, G.; Murray, P.J.; Roussel, M.F.; Schulman, B.A.
    E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification (2009), Mol. Cell, 33, 483-495 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.34

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine Mus musculus
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 [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine
-
 Mus musculus [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
NEDD8 E2
-
 Mus musculus
NEDD8-conjugating enzyme
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 Mus musculus
Ubc12
-
 Mus musculus
UBE2F
-
 Mus musculus
UBE2M
-
 Mus musculus

General Information

General Information Comment Organism
malfunction knocking down Ube2m leads to decreased Nedd8-ylation of endogenous cullins 1-4, and a marginal increase in Nedd8-modified cullin 5 By contrast, knocking down Ube2f virtually eliminates the presence of Nedd8-ylated cullin 5, and has no effect on the levels of Nedd8-modified cullins 1-4 Mus musculus