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Literature summary for 2.3.2.34 extracted from

  • Zhou, W.; Xu, J.; Tan, M.; Li, H.; Li, H.; Wei, W.; Sun, Y.
    UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F (2018), Mol. Cell, 70, 1008-1024 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine Homo sapiens
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 [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-427 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H2170 cell
-
 Homo sapiens
-
NCI-H358 cell
-
 Homo sapiens
-
SK-MES-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
neddylation conjugating E2 enzyme
-
 Homo sapiens
Ubc12
-
 Homo sapiens
UBE2F
-
 Homo sapiens
UBE2M
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens UBE2M is a stress-inducible gene subjected to cis-trans-activation by hypoxia-inducible factor-1alpha and transcription factor AP-1. MLN4924, a small molecule inhibitor of E1 NEDD8-activating enzyme, up-regulates UBE2M via blocking degradation of hypoxia-inducible factor-1alpha and transcription factor AP-1 up

General Information

General Information Comment Organism
physiological function UBE2M is a dual E2 for targeted ubiquitylation and degradation of UBE2F, acting as a neddylation E2 to activate cullin 3-Keap1 E3 under physiological condition, but as an ubiquitylation E2 for Parkin-DJ-1 E3 under stressed conditions. UBE2M-induced UBE2F degradation leads to CRL5 inactivation and subsequent NOXA accumulation to suppress the growth of lung cancer cells Homo sapiens