Literature summary for 2.3.2.34 extracted from

Li, L.; Kang, J.; Zhang, W.; Cai, L.; Wang, S.; Liang, Y.; Jiang, Y.; Liu, X.; Zhang, Y.; Ruan, H.; Chen, G.; Wang, M.; Jia, L.
Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer (2019), EBioMedicine, 45, 81-91 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine	Homo sapiens	-	[E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HCC-1438 cell	-	Homo sapiens	-
HCC-1833 cell	-	Homo sapiens	-
HCC-827 cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-
NCI-H1838 cell	-	Homo sapiens	-
NCI-H1975 cell	-	Homo sapiens	-
NCI-H2030 cell	-	Homo sapiens	-
NCI-H596 cell	-	Homo sapiens	-
PC-9 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine	-	Homo sapiens	[E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine	-	?

Subunits

Subunits	Comment	Organism
?	x * 20000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
NEDD8-conjugating enzyme E2	-	Homo sapiens
neddylation conjugating enzyme	-	Homo sapiens
Ubc12	-	Homo sapiens
UBE2M	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	UBC12 pairs with RBX1/ROC1 to regulate the neddylation of cullin 1, 2, 3, 4a, 4b and 7, while UBE2F pairs with RBX2/ROC2 to regulate the neddylation of cullin 5	Homo sapiens

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Release 2023.1 (January 2023)