Reference on EC 2.3.2.32 - cullin-RING-type E3 NEDD8 transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Onel, M.; Sumbul, F.; Liu, J.; Nussinov, R.; Haliloglu, T.
Cullin neddylation may allosterically tune polyubiquitin chain length and topology
Biochem. J.
474
781-795
2017
Homo sapiens (P62877)
Duda, D.; Borg, L.; Scott, D.; Hunt, H.; Hammel, M.; Schulman, B.
Structural insights into NEDD8 activation of Cullin-RING ligases conformational control of conjugation
Cell
134
995-1006
2008
Homo sapiens
Scott, D.; Sviderskiy, V.; Monda, J.; Lydeard, J.; Cho, S.; Harper, J.; Schulman, B.
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
Cell
157
1671-1684
2014
Homo sapiens
Dharmasiri, S.; Dharmasiri, N.; Hellmann, H.; Estelle, M.
The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis
EMBO J.
22
1762-1770
2003
Arabidopsis thaliana
Bagchi, R.; Melnyk, C.; Christ, G.; Winkler, M.; Kirchsteiner, K.; Salehin, M.; Mergner, J.; Niemeyer, M.; Schwechheimer, C.; Caldern Villalobos, L.; Estelle, M.
The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases
EMBO J.
37
255-268
2018
Arabidopsis thaliana
Megumi, Y.; Miyauchi, Y.; Sakurai, H.; Nobeyama, H.; Lorick, K.; Nakamura, E.; Chiba, T.; Tanaka, K.; Weissman, A.; Kirisako, T.; Ogawa, O.; Iwai, K.
Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex
Genes Cells
10
679-691
2005
Homo sapiens
Kamura, T.; Conrad, M.; Yan, Q.; Conaway, R.; Conaway, J.
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
Genes Dev.
13
2928-2933
1999
Homo sapiens
Kim, A.; Bommelje, C.; Lee, B.; Yonekawa, Y.; Choi, L.; Morris, L.; Huang, G.; Kaufman, A.; Ryan, R.; Hao, B.; Ramanathan, Y.; Singh, B.
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
J. Biol. Chem.
283
33211-33220
2008
Mus musculus
-
Huang, G.; Kaufman, A.; Ramanathan, Y.; Singh, B.
SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex
J. Biol. Chem.
286
10297-10304
2011
Homo sapiens
Kurz, T.; Chou, Y.; Willems, A.; Meyer-Schaller, N.; Hecht, M.; Tyers, M.; Peter, M.; Sicheri, F.
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation
Mol. Cell.
29
23-35
2008
Saccharomyces cerevisiae (Q12395)
Huang, D.; Ayrault, O.; Hunt, H.; Taherbhoy, A.; Duda, D.; Scott, D.; Borg, L.; Neale, G.; Murray, P.; Roussel, M.; Schulman, B.
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol. Cell.
33
483-495
2009
Homo sapiens
Scott, D.; Monda, J.; Grace, C.; Duda, D.; Kriwacki, R.; Kurz, T.; Schulman, B.
A dual E3 mechanism for Rub1 ligation to Cdc53
Mol. Cell.
39
784-796
2010
Saccharomyces cerevisiae
Xu, J.; Li, L.; Yu, G.; Ying, W.; Gao, Q.; Zhang, W.; Li, X.; Ding, C.; Jiang, Y.; Wei, D.; Duan, S.; Lei, Q.; Li, P.; Shi, T.; Qian, X.; Qin, J.; Jia, L.
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer
Mol. Cell. Proteomics
14
499-509
2015
Homo sapiens
Sakata, E.; Yamaguchi, Y.; Miyauchi, Y.; Iwai, K.; Chiba, T.; Saeki, Y.; Matsuda, N.; Tanaka, K.; Kato, K.
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
Nat. Struct. Mol. Biol.
14
167-168
2007
Homo sapiens
Rahighi, S.; Dikic, I.
Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases
Nat. Struct. Mol. Biol.
18
863-865
2011
Homo sapiens
-
Calabrese, M.; Scott, D.; Duda, D.; Grace, C.; Kurinov, I.; Kriwacki, R.; Schulman, B.
A RING E3-substrate complex poised for ubiquitin-like protein transfer Structural insights into cullin-RING ligases
Nat. Struct. Mol. Biol.
18
947-949
2011
Homo sapiens
Kurz, T.; zl, N.; Rudolf, F.; ORourke, S.; Luke, B.; Hofmann, K.; Hyman, A.; Bowerman, B.; Peter, M.
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
Nature
435
1257-1261
2005
Saccharomyces cerevisiae, Caenorhabditis elegans
Gray, W.; Hellmann, H.; Dharmasiri, S.; Estelle, M.
Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function
Plant Cell
14
2137-2144
2002
Arabidopsis thaliana
Monda, J.; Scott, D.; Miller, D.; Lydeard, J.; King, D.; Harper, J.; Bennett, E.; Schulman, B.
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes
Structure
21
42-53
2013
Homo sapiens
Cardote, T.A.F.; Ciulli, A.
Structure-guided design of peptides as tools to probe the protein-protein interaction between cullin-2 and elongin BC substrate adaptor in cullin RING E3 ubiquitin ligases
ChemMedChem
12
1491-1496
2017
Homo sapiens (Q13617)
Coleman, K.E.; Bekes, M.; Chapman, J.R.; Crist, S.B.; Jones, M.J.; Ueberheide, B.M.; Huang, T.T.
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
eLife
6
e24325
2017
Homo sapiens (P62877)
Faull, S.V.; Lau, A.M.C.; Martens, C.; Ahdash, Z.; Hansen, K.; Yebenes, H.; Schmidt, C.; Beuron, F.; Cronin, N.B.; Morris, E.P.; Politis, A.
Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
Nat. Commun.
10
3814
2019
Homo sapiens (Q13617)
Baek, K.; Krist, D.T.; Prabu, J.R.; Hill, S.; Kluegel, M.; Neumaier, L.M.; von Gronau, S.; Kleiger, G.; Schulman, B.A.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Nature
578
461-466
2020
Homo sapiens (P62877)
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