Literature summary for 2.3.2.32 extracted from

Cardote, T.A.F.; Ciulli, A.
Structure-guided design of peptides as tools to probe the protein-protein interaction between cullin-2 and elongin BC substrate adaptor in cullin RING E3 ubiquitin ligases (2017), ChemMedChem, 12, 1491-1496 .

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Application

Application	Comment	Organism
analysis	development of peptides to probe the protein-protein interaction between the cullin-2 scaffold protein and the adaptor subunit elongin BC within the context of the von Hippel-Lindau complex. Peptides MSLKPRVV and MS-cyclohexylglycine-KPRVV can disrupt the native interaction between the von Hippel-Landau complex and Cul2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13617	isoform cullin-2	-

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Release 2023.1 (January 2023)