Literature summary for 2.3.2.32 extracted from

Coleman, K.E.; Bekes, M.; Chapman, J.R.; Crist, S.B.; Jones, M.J.; Ueberheide, B.M.; Huang, T.T.
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function (2017), eLife, 6, e24325 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P62877	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Ubc12, a NEDD8-specific E2 conjugating enzyme, is a substrate for auto-neddylation. Protease SENP8/DEN1 counteracts Ubc12 autoneddylation, and aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components is observed in SENP8-deficient cells	Homo sapiens	?	-	-
[E2 NEDD8-conjugating enzyme Ubc12]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine	-	Homo sapiens	[E2 NEDD8-conjugating enzyme Ubc12]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
RBX1	-	Homo sapiens

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Release 2023.1 (January 2023)