Literature summary for 2.3.2.32 extracted from

Thomas, Y.; Scott, D.C.; Kristariyanto, Y.A.; Rinehart, J.; Clark, K.; Cohen, P.; Kurz, T.
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation (2018), PLoS ONE, 13, e0199197 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BTE7	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	DCNL5 is a direct substrate of the kinase IKKalpha during immune signalling. Upon activation of Toll-like receptors, DCNL5 gets rapidly and transiently phosphorylated on N-terminal serine residue S41	Homo sapiens

Synonyms

Synonyms	Comment	Organism
DCN1-like protein 5	-	Homo sapiens
DCNL5	-	Homo sapiens
DCUN1D5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	DCNL5 assists Cullin-bound RING-finger protein in neddylation and may be involved in innate immunity. DCNL5 is a direct substrate of the kinase IKKalpha during immune signalling. Upon activation of Toll-like receptors, DCNL5 gets rapidly and transiently phosphorylated on N-terminal serine residue S41. The phosphorylation is specifically mediated by IKKalpha and not IKKbeta	Homo sapiens

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Release 2023.1 (January 2023)