2.3.1.298: ultra-long-chain ceramide synthase

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For detailed information about ultra-long-chain ceramide synthase, go to the full flat file.

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Synonyms

(dihydro)ceramide synthase, ceramide synthase, ceramide synthase 3, CerS3, LASS3, LASS3-long, longevity assurance homologue 3, mammalian ceramide synthase 3, phytoceramide synthase, sphingoid base N-ultra-long-chain fatty acyl-coA transferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.298 ultra-long-chain ceramide synthase

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Results	in table
2	Activating Compound
4	AA Sequence
9	Cloned(Commentary)
5	Expression
14	General Information
6	Inhibitors
1	Localization
1	Metals/Ions
24	Natural Substrates/ Products (Substrates)
20	Organism
3	Pathway
3	pH Optimum
4	pI Value
1	Posttranslational Modification
2	Protein Variants
1	Reaction
19	Reference
35	Source Tissue
66	Substrates and Products (Substrate)
6	Subunits
37	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.1.298 - ultra-long-chain ceramide synthase

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ultra-long-chain fatty acyl-coA:sphingoid base N-acyltransferase

Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 3 (CERS3) is the only enzyme that is active with ultra-long-chain acyl-CoA donors (C28 or longer). It is active in the epidermis, where its products are incorporated into acylceramides. CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty acids, and can accept very-long-chain acyl-CoA substrates (see EC 2.3.1.297, very-long-chain ceramide synthase). It can use multiple sphingoid bases including sphinganine, sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine.