2.3.1.298: ultra-long-chain ceramide synthase
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Synonyms
(dihydro)ceramide synthase, ceramide synthase, ceramide synthase 3, CerS3, LASS3, LASS3-long, longevity assurance homologue 3, mammalian ceramide synthase 3, phytoceramide synthase, sphingoid base N-ultra-long-chain fatty acyl-coA transferase
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Source Tissue
Source Tissue on EC 2.3.1.298 - ultra-long-chain ceramide synthase
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epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview. Upon differentiation, CerS3 mRNA expression significantly increases and remains high throughout differentiation
aged skin shows decreased levels of stratum corneum ceramides. Comparison of activities of epidermal A-SMase, ceramide synthase, and ceramidase in chronologically aged versus young hairless mouse skin. Reduced A-SMase and ceramide synthase activities are found in the epidermis of aged mice, but ceramidase activity is not age-dependent
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the enzyme is expressed in the upper stratum spinosum and stratum granulosumof the skin
Mus musculus SKH-1
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aged skin shows decreased levels of stratum corneum ceramides. Comparison of activities of epidermal A-SMase, ceramide synthase, and ceramidase in chronologically aged versus young hairless mouse skin. Reduced A-SMase and ceramide synthase activities are found in the epidermis of aged mice, but ceramidase activity is not age-dependent
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aged skin shows decreased levels of stratum corneum ceramides