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2.3.1.298: ultra-long-chain ceramide synthase

This is an abbreviated version!
For detailed information about ultra-long-chain ceramide synthase, go to the full flat file.

Reaction

an ultra-long-chain fatty acyl-CoA
+
a sphingoid base
=
an ultra-long-chain ceramide
 +
CoA

Synonyms

(dihydro)ceramide synthase, ceramide synthase, ceramide synthase 3, CerS3, LASS3, LASS3-long, longevity assurance homologue 3, mammalian ceramide synthase 3, phytoceramide synthase, sphingoid base N-ultra-long-chain fatty acyl-coA transferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.298 ultra-long-chain ceramide synthase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.298 - ultra-long-chain ceramide synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
an ultra-long-chain fatty acyl-CoA + a sphingoid base
an ultra-long-chain ceramide + CoA
show the reaction diagram
an ultra-long-chain fatty acyl-CoA + phytosphingosine
phytoceramide + CoA
show the reaction diagram
-
-
-
-
?
an ultra-long-chain fatty acyl-CoA + sphingosine
an ultra-long-chain ceramide + CoA
show the reaction diagram
-
the enzyme uses acyl-CoAs longer than 26 carbon atoms in length
-
-
?
fatty acyl-CoA + dihydrosphingosine
ceramide + CoA
show the reaction diagram
-
-
-
?
sphingosine + behenoyl-CoA
N-behenoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + cerotoyl-CoA
N-cerotoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + eicosanoyl-CoA
N-eicosanoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + lignoceroyl-CoA
N-lignoceroylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + montanoyl-CoA
N-montanoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + stearoyl-CoA
N-stearoylsphingosine + CoA
show the reaction diagram
-
-
-
?
additional information
?
-
CERS3 transfers much longer chain fatty acids (C26, C28), forming highly hydrophobic ceramides that are a very important part of the water barrier function of skin
-
-
?