2.1.1.357: [histone H3]-lysine36 N-dimethyltransferase
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For detailed information about [histone H3]-lysine36 N-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
Ash1L, EC 2.1.1.43, H3K36 KMTase, H3K36 methyltransferase, H3K36-specific methyltransferase, histone H3 lysine 36 methyltransferase, KMT3B, KMT3C, Metnase, MMSET, NSD1, NSD2, NSD3, nuclear receptor SET domain containing protein 2, nuclear receptor-binding SET domain protein 2, SET, SETD2, SETMAR, Smyd2, Whsc1, WHSC1L1
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.357 - [histone H3]-lysine36 N-dimethyltransferase
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S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-dimethyltransferase
This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. Some enzymes can catalyse three methylations, forming a trimethylated form; these enzymes are classified under EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase.