2.1.1.357: [histone H3]-lysine36 N-dimethyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine36 N-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.357
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
Ash1L, EC 2.1.1.43, H3K36 KMTase, H3K36 methyltransferase, H3K36-specific methyltransferase, histone H3 lysine 36 methyltransferase, KMT3B, KMT3C, Metnase, MMSET, NSD1, NSD2, NSD3, nuclear receptor SET domain containing protein 2, nuclear receptor-binding SET domain protein 2, SET, SETD2, SETMAR, Smyd2, Whsc1, WHSC1L1
ECTree
2.1.1.357 [histone H3]-lysine36 N-dimethyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.357 - [histone H3]-lysine36 N-dimethyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
2 S-adenosyl-L-methionine + [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-homocysteine + nuclear factor-kappaB
?
NSD1 also methylates nonhistone proteins, including the p65 subunit of nuclear factor-kappaB at Lys218 and Lys221
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
S-adenosyl-L-methionine + chicken nucleosome
S-adenosyl-L-homocysteine + chicken nucleosome N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + recombinant nucleosome
S-adenosyl-L-homocysteine + recombinant nucleosome N6-methyl-L-lysine
-
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
preferred reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
additional information
?
-
enzyme mono- and dimethylates H3K36 and is inactive with H3K4 as substrate. Nucleosome containing histone H3 mutant K36A or histone H3 peptide 18-44 are not substrates. Isoform SETD2 is able to trimethylate H3K36 in vitro
-
-
?
additional information
?
-
the catalytic domain does not methylate recombinant nucleosomes containing histone H3 K36A mutants
-
-
?
additional information
?
-
enzyme shows versatilitiy in substrate recognition. In a pan-methylation assay of histone H3, H3K4me3 and H3K27me3 species are preferably detected rather than me1 and me2 species, while H3K9-me1 and -me2 and H3K79-me1 and -me2 species are favored against me3 species. H3K36 appears to be the preferable in vitro substrate for NSD1-C-terminal domain. NSD1 shows mono-/tri-methylation of histone H4K20
-
-
-
additional information
?
-
the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA
-
-
?
